L
Liesbet Martens
Researcher at Ghent University
Publications - 31
Citations - 4278
Liesbet Martens is an academic researcher from Ghent University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 19, co-authored 26 publications receiving 2586 citations. Previous affiliations of Liesbet Martens include Flanders Institute for Biotechnology.
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Journal ArticleDOI
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Charlotte L. Scott,Fang Zheng,Fang Zheng,Patrick De Baetselier,Liesbet Martens,Yvan Saeys,Sofie De Prijck,Saskia Lippens,Chloé Abels,Steve Schoonooghe,Geert Raes,Nick Devoogdt,Bart N. Lambrecht,Alain Beschin,Martin Guilliams +14 more
TL;DR: It is shown that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells, like embryonic precursors if the niche is available to them.
Journal ArticleDOI
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Hannah Van Hove,Liesbet Martens,Isabelle Scheyltjens,Karen De Vlaminck,Ana Rita Pombo Antunes,Sofie De Prijck,Niels Vandamme,Sebastiaan De Schepper,Gert Van Isterdael,Charlotte L. Scott,Charlotte L. Scott,Jeroen Aerts,Geert Berx,Guy E. Boeckxstaens,Roosmarijn E. Vandenbroucke,Lars Vereecke,Diederik Moechars,Martin Guilliams,Jo A. Van Ginderachter,Yvan Saeys,Kiavash Movahedi +20 more
TL;DR: The results provide a framework for understanding host–macrophage interactions in both the healthy and diseased brain and identify IRF8 as a master regulator that drives the maturation and diversity of brain macrophages.
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Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages
Lianne van de Laar,Wouter Saelens,Sofie De Prijck,Liesbet Martens,Charlotte L. Scott,Gert Van Isterdael,Eik Hoffmann,Rudi Beyaert,Yvan Saeys,Bart N. Lambrecht,Bart N. Lambrecht,Martin Guilliams +11 more
TL;DR: Precursor origin does not affect the development of functional self-maintaining tissue-resident macrophages and the plasticity of the mononuclear phagocyte system is largest at the precursor stage.
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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Johnny Bonnardel,Wouter T’Jonck,Djoere Gaublomme,Robin Browaeys,Charlotte L. Scott,Liesbet Martens,Bavo Vanneste,Sofie De Prijck,Sergei A. Nedospasov,Anna Kremer,Evelien Van Hamme,Peter Borghgraef,Wendy Toussaint,Pieter De Bleser,Inge Mannaerts,Alain Beschin,Leo A. van Grunsven,Bart N. Lambrecht,Tom Taghon,Saskia Lippens,Dirk Elewaut,Yvan Saeys,Martin Guilliams +22 more
TL;DR: It is shown that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Journal ArticleDOI
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver
Anneleen Remmerie,Liesbet Martens,Tinne Thoné,Angela Castoldi,Ruth Seurinck,Benjamin Pavie,Joris Roels,Bavo Vanneste,Sofie De Prijck,Mathias Vanhockerhout,Mushida Binte Abdul Latib,Lindsey Devisscher,Anne Hoorens,Johnny Bonnardel,Niels Vandamme,Anna Kremer,Peter Borghgraef,Hans Van Vlierberghe,Saskia Lippens,Edward J. Pearce,Edward J. Pearce,Yvan Saeys,Charlotte L. Scott +22 more
TL;DR: It is demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow, highlighting considerable heterogeneity within the macrophage pool and suggesting a need for more specificmacrophage targeting strategies inMAFLD.