K
Kiichiro Tomoda
Researcher at Osaka Medical College
Publications - 33
Citations - 24267
Kiichiro Tomoda is an academic researcher from Osaka Medical College. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 18, co-authored 30 publications receiving 21439 citations. Previous affiliations of Kiichiro Tomoda include University of California, San Francisco & Gladstone Institutes.
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BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
Yohei Hayashi,Edward C. Hsiao,Salma Sami,Mariselle Lancero,Christopher R. Schlieve,Trieu Nguyen,Koyori Yano,Ayako Nagahashi,Makoto Ikeya,Yoshihisa Matsumoto,Yoshihisa Matsumoto,Ken Nishimura,Aya Fukuda,Koji Hisatake,Kiichiro Tomoda,Isao Asaka,Junya Toguchida,Bruce R. Conklin,Shinya Yamanaka +18 more
TL;DR: Evidence is provided that the BMP-SMAD-ID signaling axis suppressed p16/INK4A-mediated cell senescence during the early phase in iPSC generation, a major barrier to reprogramming.
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Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells.
Cody Kime,Hiroshi Kiyonari,Satoshi Ohtsuka,Eiko Kohbayashi,Michio Asahi,Shinya Yamanaka,Masayo Takahashi,Kiichiro Tomoda +7 more
TL;DR: In this paper, an induced self-organizing 3D blastocyst-like cysts (iBLCs) were generated from mouse pluripotent stem cells (PSC) culture.
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Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation
TL;DR: The small Jab1‐containing subcomplex may be a novel mediator of anchorage and cell–cell contact‐dependent signal transduction in cell proliferation, differentiation, and tumorigenesis.
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Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Yohei Hayashi,Laura Caboni,Debanu Das,Fumiaki Yumoto,Thomas Clayton,Marc C. Deller,Phuong Nguyen,Carol L. Farr,Hsiu-Ju Chiu,Mitchell D. Miller,Marc-André Elsliger,Ashley M. Deacon,Adam Godzik,Adam Godzik,Scott A. Lesley,Scott A. Lesley,Kiichiro Tomoda,Bruce R. Conklin,Bruce R. Conklin,Ian A. Wilson,Shinya Yamanaka,Shinya Yamanaka,Robert J. Fletterick +22 more
TL;DR: The crystal structure of the human NANOG homeodomain (hNANOG HD) bound to an OCT4 promoter DNA was determined, which revealed amino acid residues involved in DNA recognition that are likely to be functionally important and suggest that these residues are critical for NANog transcriptional activity.
Journal ArticleDOI
Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1.
Yoriko Sugiyama,Kiichiro Tomoda,Toshiaki Tanaka,Yukinobu Arata,Noriko Yoneda-Kato,Jun-ya Kato +5 more
TL;DR: It is shown that Grb2 and Grb3-3, the molecules functioning as an adaptor in the signal transduction pathway, specifically and directly bind to p27 in the cytoplasm and participate in the regulation of p27.