K
Kim L. Powell
Researcher at Monash University
Publications - 54
Citations - 2068
Kim L. Powell is an academic researcher from Monash University. The author has contributed to research in topics: Epilepsy & Epileptogenesis. The author has an hindex of 19, co-authored 52 publications receiving 1730 citations. Previous affiliations of Kim L. Powell include University of Melbourne & Australian National University.
Papers
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Journal ArticleDOI
The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore
TL;DR: It is reported that overexpression alone of a purinergic P2x7R, in the absence of pathological insults, is sufficient to drive the activation and proliferation of microglia in rat primary hippocampal cultures and evidence is provided for a novel trophic role for P2X7R pore inmicroglia.
Journal ArticleDOI
T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures
Elizabeth Tringham,Kim L. Powell,Stuart M. Cain,Kristy Kuplast,Janette Mezeyova,Manjula Weerapura,Cyrus Eduljee,Xinpo Jiang,Paula L. Smith,Jerrie Lynn Morrison,Nigel C. Jones,Emma L. Braine,Gil S. Rind,Molly Fee-Maki,David Parker,Hassan Pajouhesh,Manjeet Parmar,Terence J. O'Brien,Terrance P. Snutch +18 more
TL;DR: The ability of the T-type Ca2+ channel antagonists to inhibit absence seizures and to reduce the duration and cycle frequency of spike-and-wave discharges suggests that these agents have a unique mechanism of action on pathological thalamocortical oscillatory activity distinct from current drugs used in clinical practice.
Journal ArticleDOI
A Cav3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy
Kim L. Powell,Stuart M. Cain,Caroline Ng,Shreerang Sirdesai,Laurence S. David,Mervyn Kyi,Esperanza Garcia,John R. Tyson,Christopher A. Reid,Melanie Bahlo,Simon J. Foote,Terrance P. Snutch,Terence J. O'Brien +12 more
TL;DR: A homozygous, missense, single nucleotide (G to C) mutation in the Cav3.2 T-type Ca2+ channel gene (Cacna1h) in the genetic absence epilepsy rats from Strasbourg (GAERS) model has a novel mechanism of action, being dependent on exonic splicing for its functional consequences to be expressed.
Journal Article
A cav3.2 t-type calcium channel point mutation has splice variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy
Caroline Ng,Kim L. Powell,Stuart M. Cain,S Sirdesai,Laurence S. David,Mervyn Kyi,Esperanza Garcia,John R. Tyson,Christopher A. Reid,Melanie Bahlo,Simon J. Foote,Terrance P. Snutch,Terence J. O'Brien +12 more
TL;DR: In this paper, a homozygous, missense, single nucleotide (G to C) mutation in the Cav3.2 T-type Ca2+ channel gene (Cacna1h) in the genetic absence epilepsy rats from Strasbourg (GAERS) model was described.
Journal ArticleDOI
Glutamate is associated with a higher risk of seizures in patients with gliomas
Tanya I. Yuen,Andrew P. Morokoff,Andrew R. Bjorksten,Giovanna M. D'Abaco,Lucy Paradiso,Sue Finch,Daniel Wong,Christopher A. Reid,Kim L. Powell,Kate Drummond,Mark Rosenthal,Andrew H. Kaye,Terence J. O'Brien +12 more
TL;DR: In this article, the authors investigated the relationship of glutamate and glutamate transporter expression in human gliomas and surrounding peritumoral brain to the presence of tumor-associated seizures.