Kira I. Mosher

TL;DR: Heterochronic parabiosis shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice, and identifies chemokines—including CCL11 (also known as eotaxin)—the plasma levels of which correlate with reduced neuroGenesis in heterochronics parabionts and aged mice and which are increased in the plasma and cerebrospinal fluid of healthy ageing humans.

TL;DR: Exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function, and structural and cognitive enhancements elicited by exposure are mediated by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus.

TL;DR: In this review, six distinct functions of microglia are enumerated and the specific effects of both aging and AD are discussed to inspire new approaches for dissecting microglial mechanisms.

TL;DR: It is shown that the autophagy protein beclin 1 is required for efficient phagocytosis in vitro and in mouse brains and that microglia isolated from human Alzheimer's disease (AD) brains show significantly reduced beClin 1 and retromer protein levels.

TL;DR: It is shown that human Cord plasma treatment revitalizes the hippocampus and improves cognitive function in aged mice and reveals that human cord plasma contains plasticity-enhancing proteins of high translational value for targeting ageing- or disease-associated hippocampal dysfunction.