Zhaoqing Ding

TL;DR: Heterochronic parabiosis shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice, and identifies chemokines—including CCL11 (also known as eotaxin)—the plasma levels of which correlate with reduced neuroGenesis in heterochronics parabionts and aged mice and which are increased in the plasma and cerebrospinal fluid of healthy ageing humans.

TL;DR: The results represent a proof of concept for the design of HA stem mimics that elicit bnAbs against influenza A group 1 viruses and completely protects mice in lethal heterologous and heterosubtypic challenge models, and reduces fever after sublethal challenge in cynomolgus monkeys.

TL;DR: The data emphasize the importance of Id2 in regulating gene expression by CD8+ T cells and the magnitude of effector responses, suggesting a mechanism involving Id protein– and E protein–mediated survival and differentiation of mature T cells.

TL;DR: Colony-stimulating factor 1 and IL-34 protect against and partially reverse neurodegeneration in mice in part via promoting CREB signaling.

TL;DR: Ang II is identified as a paracrine mediator, sustaining inflammation in the CNS in the EAE mouse model of MS via TGF-beta, suggesting that AT1R antagonists, frequently prescribed as antihypertensives, may be useful to interrupt this proinflammatory, CNS-specific pathway in individuals with MS.