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Diego Mastroeni

Researcher at Arizona State University

Publications -  76
Citations -  5724

Diego Mastroeni is an academic researcher from Arizona State University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 29, co-authored 71 publications receiving 4860 citations. Previous affiliations of Diego Mastroeni include University of Exeter & Maastricht University.

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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

TL;DR: Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
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Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

TL;DR: These findings suggest epigenetic dysfunction in AD-vulnerable neurons, and show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases.
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The epigenetics of aging and neurodegeneration.

TL;DR: Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.