D
Diego Mastroeni
Researcher at Arizona State University
Publications - 76
Citations - 5724
Diego Mastroeni is an academic researcher from Arizona State University. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 29, co-authored 71 publications receiving 4860 citations. Previous affiliations of Diego Mastroeni include University of Exeter & Maastricht University.
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Journal ArticleDOI
Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
Winnie S. Liang,Eric M. Reiman,Jon Valla,Travis Dunckley,Thomas G. Beach,Andrew Grover,Tracey L. Niedzielko,Lonnie Schneider,Diego Mastroeni,Richard J. Caselli,Walter A. Kukull,John C. Morris,Christine M. Hulette,Donald E. Schmechel,Joseph M. Rogers,Dietrich A. Stephan +15 more
TL;DR: Molecular evaluation of cells from metabolically affected brain regions could provide new information about the pathogenesis of AD and new targets at which to aim disease-slowing and prevention therapies.
Journal ArticleDOI
GAB2 Alleles Modify Alzheimer's Risk in APOE ε4 Carriers
Eric M. Reiman,Jennifer Webster,Amanda J. Myers,Amanda J. Myers,John Hardy,John Hardy,Travis Dunckley,Victoria Zismann,Keta Joshipura,John V. Pearson,Diane Hu-Lince,Matthew J. Huentelman,David Craig,Keith D. Coon,Keith D. Coon,Winnie S. Liang,Ri Lee H. Herbert,Thomas G. Beach,Kristen Rohrer,Alice S. Zhao,Doris G. Leung,Leslie Bryden,Lauren Marlowe,Mona Kaleem,Diego Mastroeni,Andrew Grover,Christopher B. Heward,Rivka Ravid,Joseph Rogers,Mike Hutton,Stacey Melquist,R. C. Petersen,Gene E. Alexander,Richard J. Caselli,Walter A. Kukull,Andreas Papassotiropoulos,Andreas Papassotiropoulos,Dietrich A. Stephan +37 more
TL;DR: The findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology.
Journal ArticleDOI
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
TL;DR: Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
Journal ArticleDOI
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation
Diego Mastroeni,Andrew Grover,Elaine Delvaux,Charisse M. Whiteside,Paul D. Coleman,Joseph G. Rogers +5 more
TL;DR: These findings suggest epigenetic dysfunction in AD-vulnerable neurons, and show, for the first time, neuronal immunoreactivity for all 10 of the epigenetic markers and factors, with highly significant decrements in AD cases.
Journal ArticleDOI
The epigenetics of aging and neurodegeneration.
Roy Lardenoije,Artemis Iatrou,Gunter Kenis,Konstantinos Kompotis,Harry W.M. Steinbusch,Diego Mastroeni,Paul D. Coleman,Cynthia A. Lemere,Patrick R. Hof,Daniel L.A. van den Hove,Bart P. F. Rutten +10 more
TL;DR: Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.