Sebastien Couillard-Despres

TL;DR: The transient expression pattern of DCX in neuronal committed progenitor cells/neuroblasts indicates that DCX could be developed into a suitable marker for adult neurogenesis and may provide an alternative to BrdU labeling.

TL;DR: Heterochronic parabiosis shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age-dependent fashion in mice, and identifies chemokines—including CCL11 (also known as eotaxin)—the plasma levels of which correlate with reduced neuroGenesis in heterochronics parabionts and aged mice and which are increased in the plasma and cerebrospinal fluid of healthy ageing humans.

TL;DR: It is demonstrated that quantification of DCX‐expressing cells allows for an accurate measurement of modulations in the rate of adult neurogenesis, and DCX is a valuable alternative to techniques currently used to measure the levels of Neurogenesis.

TL;DR: The analysis of the distal sciatic nerve at 2 months after crush indicated that neurofilament-deficient axons have the capacity to regrow for a long distance and to remyelinate, albeit at a slower rate.

TL;DR: Efficient growth of adult NSCs in Neurobasal medium containing B27 supplement under clonal and low-density conditions in the absence of serum or conditioned medium is described, providing an important step toward the development of standardized protocols for highly efficient in vitro expansion of N SCs from the adult central nervous system.