K
Klaus Gast
Researcher at University of Potsdam
Publications - 20
Citations - 1274
Klaus Gast is an academic researcher from University of Potsdam. The author has contributed to research in topics: Circular dichroism & Protein folding. The author has an hindex of 12, co-authored 20 publications receiving 1091 citations.
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Journal ArticleDOI
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
TL;DR: Sequence analyses based on the results imply that foldable sequences with more compact unfolded states are a more recent result of protein evolution.
Journal ArticleDOI
Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins.
Daniel Nettels,Sonja Müller-Späth,Frank Küster,Hagen Hofmann,Domminik Haenni,Stefan Rüegger,Luc Reymond,Armin Hoffmann,Jan Kubelka,Benjamin Heinz,Klaus Gast,Robert B. Best,Benjamin Schuler +12 more
TL;DR: The results indicate an important role for additional temperature-dependent interactions within the unfolded chain in the extremely hydrophilic, intrinsically disordered protein prothymosin α.
Journal ArticleDOI
Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.
Alessandro Borgia,Wenwei Zheng,Karin J. Buholzer,Madeleine B. Borgia,Anja Schüler,Hagen Hofmann,Andrea Soranno,Daniel Nettels,Klaus Gast,Alexander Grishaev,Robert B. Best,Benjamin Schuler +11 more
TL;DR: This is the first case in which SAXS and FRET have yielded even qualitatively consistent results regarding expansion in denaturant when applied to the same proteins, and this analysis demonstrates that both of these experimental probes are compatible with a common ensemble of protein configurations for eachDenaturant concentration.
Journal ArticleDOI
On the self-association potential of transmembrane tight junction proteins
Ingolf E. Blasig,Lars Winkler,B. Lassowski,Sebastian L. Mueller,Nikolaj Zuleger,Eberhard Krause,Gerd Krause,Klaus Gast,Michael Kolbe,Jörg Piontek +9 more
TL;DR: The assumption that homodimerization of transmembrane tight junction proteins may serve as a common structural feature in tight junction assembly is supported.
Journal ArticleDOI
The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines.
Uwe-Karsten Hanisch,Denise van Rossum,Yiheng Xie,Klaus Gast,Rolf Misselwitz,Seppo Auriola,Gundars Goldsteins,Jari Koistinaho,Helmut Kettenmann,Thomas Möller +9 more
TL;DR: Evidence is provided that thrombin induces the release of proinflammatory cytokines and chemokines from microglial cells, suggesting another important role for the protease beyond hemostasis and may force a revision of the notion thatThrombin itself is a direct proinflammatory release signal for microglia.