K
Klaus Pantel
Researcher at University of Hamburg
Publications - 566
Citations - 36666
Klaus Pantel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 90, co-authored 486 publications receiving 29848 citations.
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Journal ArticleDOI
Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
TL;DR: Characterization of DTCs should help to identify novel targets for biological therapies aimed to prevent metastatic relapse and understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts.
Journal ArticleDOI
Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows.
Rita Lampignano,Martin H.D. Neumann,Sabrina Weber,Vera Kloten,Andrei Herdean,Thorsten Voss,Daniel Groelz,Anna Babayan,Marco Tibbesma,Martin Schlumpberger,Francesca Chemi,Dominic G. Rothwell,Harriet Wikman,Jean-Pierre Galizzi,Inger Riise Bergheim,Hege G. Russnes,Benedetta Mussolin,Serena Bonin,Christine Voigt,Hanny Musa,Pamela Pinzani,Evi Lianidou,Ged Brady,Michael R. Speicher,Klaus Pantel,Fay Betsou,Ed Schuuring,Mikael Kubista,Wim Ammerlaan,Markus Sprenger-Haussels,Thomas Schlange,Ellen Heitzer +31 more
TL;DR: This comprehensive multicenter comparison of ccfDNA preanalytical and analytical work flows is an important contribution to establishing evidence-based guidelines for clinically feasible (pre)analytical work flows.
Journal ArticleDOI
Presence of Circulating Tumor Cells in High-Risk Early Breast Cancer During Follow-Up and Prognosis.
Elisabeth Trapp,Elisabeth Trapp,Wolfgang Janni,Christian Schindlbeck,Julia Jückstock,Ulrich Andergassen,Amelie de Gregorio,Marianna Alunni-Fabbroni,M Tzschaschel,Arkadius Polasik,Julian Koch,Thomas W. P. Friedl,Peter A. Fasching,Lothar Haeberle,Tanja Fehm,Andreas Schneeweiss,Matthias W. Beckmann,Klaus Pantel,Volkmar Mueller,Brigitte Rack,Christoph Scholz +20 more
TL;DR: The presence of CTCs 2 years after chemotherapy was associated with decreased OS and DFS, and active individualized surveillance strategies for breast cancer survivors based on biomarkers should be reconsidered.
Journal Article
Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer.
Stefan B. Hosch,Jürgen Kraus,Peter Scheunemann,Jakob R. Izbicki,Claus Schneider,Udo Schumacher,Klaus Witter,Michael R. Speicher,Klaus Pantel +8 more
TL;DR: The data provide first direct evidence for the malignant potential of micrometastatic cancer cells in esophageal cancer, and the tumorigenicity and metastatic potential of both cell lines were demonstrated in severe combined immunodeficient mice.
Journal ArticleDOI
Advancing personalized cancer therapy by detection and characterization of circulating carcinoma cells.
Sabine Riethdorf,Klaus Pantel +1 more
TL;DR: Evidence has emerged that the currently used detection methods lack sensitivity or specificity to track all CTC, especially those that have lost characteristic epithelial features, and molecular CTC analysis will provide insights into the selection of tumor cells and resistance mechanisms in patients undergoing systemic therapies.