K
Klaus Pantel
Researcher at University of Hamburg
Publications - 566
Citations - 36666
Klaus Pantel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 90, co-authored 486 publications receiving 29848 citations.
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Journal ArticleDOI
Determination of Microvessel Density by Quantitative Real-time PCR in Esophageal Cancer: Correlation with Histologic Methods, Angiogenic Growth Factor Expression, and Lymph Node Metastasis
Sonja Loges,Henning Clausen,Uta Reichelt,Michael Bubenheim,Andreas Erbersdobler,Paulus G. Schurr,Emre F. Yekebas,Gunter Schuch,Jakob R. Izbicki,Klaus Pantel,Carsten Bokemeyer,Walter Fiedler +11 more
TL;DR: These results indicate that quantification of MVD by qPCR in surgical samples of esophageal carcinoma yields similar results with immunohistology and lymph node metastases could be predicted by MVD and VEGF-C expression.
Journal ArticleDOI
Involvement of CXCR4 Chemokine Receptor in Metastastic HER2-Positive Esophageal Cancer
Stephanie J. Gros,Nina Kurschat,Astrid Drenckhan,Thorsten Dohrmann,Evelyn Forberich,Katharina E. Effenberger,Uta Reichelt,Robert M. Hoffman,Robert M. Hoffman,Klaus Pantel,Jussuf T. Kaifi,Jakob R. Izbicki +11 more
TL;DR: The correlation of CXCR4- and HER2-expression and the elevation of Her2- expression and reduction of metastases through CX CR4-inhibition suggest a possible functional linkage and a role in tumor dissemination in HER2 -positive esophageal carcinoma.
Journal ArticleDOI
Comparison of genetic alterations detected in circulating microsatellite DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia.
TL;DR: It is demonstrated that PCa patients had higher DNA concentrations in their blood circulation than BPH patients, and microsatellite analysis using plasma DNA may be an interesting tool for molecular screening of PCA patients.
Journal ArticleDOI
Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients.
Bret Taback,Armando E. Giuliano,Ron Lai,Nora M. Hansen,Frederick R. Singer,Klaus Pantel,Dave S.B. Hoon +6 more
TL;DR: Methylation patterns in the sentinel lymph node (SLN) metastasis corresponded with that of the primary tumor, confirming epigenetic clonality is associated with early tumor dissemination.
Journal ArticleDOI
Frequency of Circulating Tumor Cells (CTC) in Patients with Brain Metastases: Implications as a Risk Assessment Marker in Oligo-Metastatic Disease.
Annkathrin Hanssen,Carlotta Riebensahm,Malte Mohme,Simon A. Joosse,Janna-Lisa Velthaus,Lars Arne Berger,Christian Bernreuther,Markus Glatzel,Sonja Loges,Katrin Lamszus,Manfred Westphal,Sabine Riethdorf,Klaus Pantel,Harriet Wikman +13 more
TL;DR: It is indicated that although patients with brain metastases more seldom harbor CTCs, they are still predictive for overall survival, and C TCs might be a useful biomarker to identify oligo-metastatic NSCLC patients who might benefit from a more intense therapy.