K
Klaus Pantel
Researcher at University of Hamburg
Publications - 566
Citations - 36666
Klaus Pantel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 90, co-authored 486 publications receiving 29848 citations.
Papers
More filters
Journal ArticleDOI
Frequent detection of PIK3CA mutations in single circulating tumor cells of patients suffering from HER2-negative metastatic breast cancer.
Christin Gasch,Theresa Oldopp,Oliver Mauermann,Tobias M. Gorges,Antje Andreas,Cornelia Coith,Volkmar Müller,Tanja Fehm,Wolfgang Janni,Klaus Pantel,Sabine Riethdorf +10 more
TL;DR: Clinical relevant genomic aberrations such as mutations in the hotspot regions of exon 9 and 20 of the PIK3CA gene can be detected in single CTC and might provide insights into mechanisms of resistance to HER2‐targeted therapies.
Journal ArticleDOI
Blood-Based Analysis of Circulating Cell-Free DNA and Tumor Cells for Early Cancer Detection
TL;DR: In a Perspective, Klaus Pantel discusses prospects for use of cell-free DNA and circulating tumor cells in cancer detection.
Journal ArticleDOI
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Randi R. Mathiesen,Renathe Fjelldal,Knut Liestøl,Eldri U. Due,Jochen B. Geigl,Sabine Riethdorf,Elin Borgen,Inga H. Rye,Ida J. Schneider,Anna C. Obenauf,Oliver Mauermann,Gro Nilsen,Ole Christian Lingjærde,Anne Lise Børresen-Dale,Klaus Pantel,Michael R. Speicher,Bjørn Naume,Lars Oliver Baumbusch +17 more
TL;DR: A single‐cell array comparative genomic hybridization (SCaCGH) method providing molecular analysis of immunomorphologically detected DTCs is presented and may be a powerful tool for the molecular characterization of D TCs.
Journal ArticleDOI
Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/ progenitor cell protein profile.
Kai Bartkowiak,Marek Wieczorek,Friedrich Buck,Sönke Harder,Jennifer Moldenhauer,Katharina E. Effenberger,Klaus Pantel,Jasna Peter-Katalinic,Burkhard Brandt +8 more
TL;DR: DTC from breast cancer patients' bone marrow expressed cytokeratin 5, which further supports the hypothesis that the protein expression profile of DTC might be reminiscent of the expression profiles of the early tumor, which differs from the advanced tumor.
Journal ArticleDOI
Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the α1-adrenergic positive inotropic effect in human atrium
Michael Grimm,Pascal Haas,Birthe Willipinski-Stapelfeldt,Wolfram-Hubertus Zimmermann,Thomas Rau,Klaus Pantel,Michael Weyand,Thomas Eschenhagen +7 more
TL;DR: In this article, the authors investigated α1-adrenergic contractile effects and the role of MLC kinase (MLCK)-dependent phosphorylation of the MLC2 in human atrial muscle strips.