K
Koenraad Brusselmans
Researcher at Katholieke Universiteit Leuven
Publications - 9
Citations - 2485
Koenraad Brusselmans is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Vascular endothelial growth factor A & Vascular endothelial growth factor. The author has an hindex of 7, co-authored 9 publications receiving 2399 citations.
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Journal ArticleDOI
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
Bert Oosthuyse,Lieve Moons,Erik Storkebaum,Heike Beck,Dieter Nuyens,Koenraad Brusselmans,J. Van Dorpe,Peter Hellings,M. Gorselink,Stephane Heymans,Gregor Theilmeier,Mieke Dewerchin,Vincent Laudenbach,P. Vermylen,H. Raat,Till Acker,V. Vleminckx,L. Van Den Bosch,Neil R. Cashman,Hajime Fujisawa,Maarten R. Drost,Raf Sciot,F. Bruyninckx,Daniel J. Hicklin,Can Ince,Pierre Gressens,Florea Lupu,Karl H. Plate,Wim Robberecht,Jean-Marc Herbert,Desire Collen,Peter Carmeliet +31 more
TL;DR: The results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons.
Journal Article
Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998)
P Carmeliet,Yuval Dor,Jean-Marc Herbert,Dai Fukumura,Koenraad Brusselmans,Mieke Dewerchin,Michal Neeman,Françoise Bono,Rinat Abramovitch,Patrick H. Maxwell,Cameron J. Koch,Peter J. Ratcliffe,Lieve Moons,Rakesh K. Jain,D. Collen,Eli Keshert +15 more
Journal ArticleDOI
Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
Koenraad Brusselmans,Veerle Compernolle,Marc Tjwa,Michael S. Wiesener,Patrick H. Maxwell,Desire Collen,Peter Carmeliet +6 more
TL;DR: Pulmonary expression levels of endothelin-1 and plasma catecholamine levels were increased threefold and 12-fold respectively in WT but not in Hif2alpha(+/-) mice after hypoxia, suggesting that HIF-2alpha-mediated upregulation of these vasoconstrictors contributes to the development of hypoxic pulmonary vascular remodeling.
Journal ArticleDOI
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
Veerle Compernolle,Koenraad Brusselmans,Diego Franco,Antoon F.M. Moorman,Mieke Dewerchin,Desire Collen,Peter Carmeliet +6 more
TL;DR: HIF-1alpha is essential for proper cardiac development by modulating both neural crest migration and ventricle formation by modulation of neural crest Migration and ventRICle formation.
Journal ArticleDOI
Genetic evidence for a tumor suppressor role of HIF-2α
Till Acker,Antonio Diez-Juan,Julián Aragonés,Marc Tjwa,Koenraad Brusselmans,Lieve Moons,Dai Fukumura,Maria Paz Moreno-Murciano,Jean-Marc Herbert,Angelika M. Burger,Johanna Riedel,Gerd Elvert,Ingo Flamme,Patrick H. Maxwell,Desire Collen,Mieke Dewerchin,Rakesh K. Jain,Karl H. Plate,Peter Carmeliet +18 more
TL;DR: It is shown that overexpression of HIF-2alpha in rat glioma tumors enhances angiogenesis but reduces growth of these tumors, in part by increasing tumor cell apoptosis.