H
Hajime Fujisawa
Researcher at Nagoya University
Publications - 88
Citations - 12700
Hajime Fujisawa is an academic researcher from Nagoya University. The author has contributed to research in topics: Semaphorin & Neuropilin. The author has an hindex of 50, co-authored 88 publications receiving 12299 citations. Previous affiliations of Hajime Fujisawa include Kumamoto University & National Institute of Genetics.
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Journal ArticleDOI
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
Bert Oosthuyse,Lieve Moons,Erik Storkebaum,Heike Beck,Dieter Nuyens,Koenraad Brusselmans,J. Van Dorpe,Peter Hellings,M. Gorselink,Stephane Heymans,Gregor Theilmeier,Mieke Dewerchin,Vincent Laudenbach,P. Vermylen,H. Raat,Till Acker,V. Vleminckx,L. Van Den Bosch,Neil R. Cashman,Hajime Fujisawa,Maarten R. Drost,Raf Sciot,F. Bruyninckx,Daniel J. Hicklin,Can Ince,Pierre Gressens,Florea Lupu,Karl H. Plate,Wim Robberecht,Jean-Marc Herbert,Desire Collen,Peter Carmeliet +31 more
TL;DR: The results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons.
Journal ArticleDOI
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
Christiana Ruhrberg,Holger Gerhardt,Matthew Golding,Rose Watson,Sofia Ioannidou,Hajime Fujisawa,Christer Betsholtz,David T. Shima +7 more
TL;DR: It is concluded that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern.
Journal ArticleDOI
A requirement for neuropilin-1 in embryonic vessel formation
Takahiko Kawasaki,Takashi Kitsukawa,Yoko Bekku,Yoichi Matsuda,Makoto Sanbo,Takeshi Yagi,Hajime Fujisawa +6 more
TL;DR: The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neurop Pilin 1 plays roles in embryonic vessel formation, as well as nerve fiber guidance in embryogenesis.
Journal ArticleDOI
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
Takuya Takahashi,Alyson E. Fournier,Fumio Nakamura,Li Hsien Wang,Yasunori Murakami,Robert G. Kalb,Hajime Fujisawa,Stephen M. Strittmatter +7 more
TL;DR: The finding that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex is found and physiologic Sema3A receptors consist of NP-1/plexin complexes.
Journal ArticleDOI
Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice.
Takashi Kitsukawa,Masayuki Shimizu,Makoto Sanbo,Tatsumi Hirata,Masahiko Taniguchi,Yoko Bekku,Takeshi Yagi,Hajime Fujisawa +7 more
TL;DR: In this paper, the role of neuropilin-semaphorin-III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents.