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Antonio Diez-Juan
Researcher at Spanish National Research Council
Publications - 40
Citations - 2641
Antonio Diez-Juan is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Stem cell & Mitochondrial DNA. The author has an hindex of 24, co-authored 40 publications receiving 2380 citations. Previous affiliations of Antonio Diez-Juan include Flanders Institute for Biotechnology & Katholieke Universiteit Leuven.
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Journal ArticleDOI
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
Julián Aragonés,Martin Schneider,Martin Schneider,Martin Schneider,Katie Van Geyte,Katie Van Geyte,Peter Fraisl,Peter Fraisl,Tom Dresselaers,Massimiliano Mazzone,Massimiliano Mazzone,Ruud Dirkx,Serena Zacchigna,Serena Zacchigna,Hélène Lemieux,Nam Ho Jeoung,Diether Lambrechts,Diether Lambrechts,Tammie Bishop,Peggy Lafuste,Peggy Lafuste,Antonio Diez-Juan,Antonio Diez-Juan,Sarah K. Harten,Pieter Van Noten,Katrien De Bock,Carsten Willam,Marc Tjwa,Marc Tjwa,A. Grosfeld,Rachel Navet,Lieve Moons,Lieve Moons,Thierry VandenDriessche,Thierry VandenDriessche,Christophe Deroose,Bhathiya Wijeyekoon,Johan Nuyts,Bénédicte F. Jordan,Robert Silasi-Mansat,Florea Lupu,Mieke Dewerchin,Mieke Dewerchin,Christopher W. Pugh,Phil Salmon,Luc Mortelmans,Bernard Gallez,Frans Gorus,Johan Buyse,Francis Sluse,Robert A. Harris,Erich Gnaiger,Peter Hespel,Paul Van Hecke,Frans Schuit,Paul P. Van Veldhoven,Peter J. Ratcliffe,Myriam Baes,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +60 more
TL;DR: It is shown that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP production through activation of a Pparα pathway.
Journal ArticleDOI
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Tammie Bishop,Denis Gallagher,Alberto Pascual,Craig A. Lygate,J de Bono,L. G. Nicholls,Patricia Ortega-Sáenz,Henrik Oster,B. Wijeyekoon,A. I. Sutherland,A. Grosfeld,Julián Aragonés,Manuela Schneider,KV van Geyte,D. Teixeira,Antonio Diez-Juan,José López-Barneo,Keith M. Channon,Patrick H. Maxwell,Christopher W. Pugh,Alun M. Davies,Peter Carmeliet,Peter J. Ratcliffe +22 more
TL;DR: The observations suggest that the role of PHD3 in sympathoadrenal development extends beyond simple control of cell survival and organ mass, with functionalPHD3 being required for proper anatomical and physiological integrity of the system.
Journal ArticleDOI
Mitochondrial DNA content as a viability score in human euploid embryos: less is better
Antonio Diez-Juan,Carmen Rubio,Carlos Marin,Sebastian Martinez,Nasser Al-Asmar,M. Riboldi,Patricia Diaz-Gimeno,Diana Valbuena,Carlos Simón +8 more
TL;DR: An increased amount of mtDNA in euploid embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.
Journal ArticleDOI
Genetic evidence for a tumor suppressor role of HIF-2α
Till Acker,Antonio Diez-Juan,Julián Aragonés,Marc Tjwa,Koenraad Brusselmans,Lieve Moons,Dai Fukumura,Maria Paz Moreno-Murciano,Jean-Marc Herbert,Angelika M. Burger,Johanna Riedel,Gerd Elvert,Ingo Flamme,Patrick H. Maxwell,Desire Collen,Mieke Dewerchin,Rakesh K. Jain,Karl H. Plate,Peter Carmeliet +18 more
TL;DR: It is shown that overexpression of HIF-2alpha in rat glioma tumors enhances angiogenesis but reduces growth of these tumors, in part by increasing tumor cell apoptosis.
Journal ArticleDOI
Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells
Nahuel A. García,Imelda Ontoria-Oviedo,Hernán González-King,Antonio Diez-Juan,Pilar Sepúlveda +4 more
TL;DR: Exosome-mediated communication between CM and EC establishes a functional relationship that could have potential implications for the induction of local neovascularization during acute situations such as cardiac injury.