A
Akari Suzuki
Researcher at Kyoto University
Publications - 96
Citations - 6076
Akari Suzuki is an academic researcher from Kyoto University. The author has contributed to research in topics: Genome-wide association study & Arthritis. The author has an hindex of 34, co-authored 82 publications receiving 4746 citations.
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Journal ArticleDOI
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
Akari Suzuki,Ryo Yamada,Xiaotian Chang,Shinya Tokuhiro,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Makiko Nakayama-Hamada,Reimi Kawaida,Mitsuru Ono,Masahiko Ohtsuki,Hidehiko Furukawa,Shinichi Yoshino,Masao Yukioka,Shigeto Tohma,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Yuichi Nishioka,Akihiro Sekine,Aritoshi Iida,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +24 more
TL;DR: The results imply that the PADI4 haplotype associated with susceptibility to rheumatoid arthritis increases production of citrullinated peptides acting as autoantigens, resulting in heightened risk of developing the disease.
Journal ArticleDOI
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
Shinya Tokuhiro,Ryo Yamada,Xiaotian Chang,Akari Suzuki,Yuta Kochi,Tetsuji Sawada,Masakatsu Suzuki,Miyuki Nagasaki,Masahiko Ohtsuki,Mitsuru Ono,Hidehiko Furukawa,Masakazu Nagashima,Shinichi Yoshino,Akihiko Mabuchi,Akihiro Sekine,Susumu Saito,Atsushi Takahashi,Tatsuhiko Tsunoda,Yusuke Nakamura,Kazuhiko Yamamoto +19 more
TL;DR: The data indicate that the regulation of SLC22A4 expression by RUNX1 is associated with susceptibility to rheumatoid arthritis, which may represent an example of an epistatic effect of two genes on this disorder.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
A cross-population atlas of genetic associations for 220 human phenotypes
Saori Sakaue,Masahiro Kanai,Yosuke Tanigawa,Juha Karjalainen,Mitja I. Kurki,Seizo Koshiba,Akira Narita,Takahiro Konuma,Kenichi Yamamoto,Masato Akiyama,Kazuyoshi Ishigaki,Akari Suzuki,Ken Suzuki,Wataru Obara,Ken Yamaji,Kazuhisa Takahashi,Satoshi Asai,Yasuo Takahashi,Takao Suzuki,Nobuaki Shinozaki,Hiroki Yamaguchi,Shiro Minami,Shigeo Murayama,Kozo Yoshimori,Satoshi Nagayama,Daisuke Obata,Masahiko Higashiyama,Akihide Masumoto,Yukihiro Koretsune,FinnGen,Kaoru Ito,Chikashi Terao,Toshimasa Yamauchi,Issei Komuro,Takashi Kadowaki,Gen Tamiya,Masayuki Yamamoto,Yusuke Nakamura,Yusuke Nakamura,Michiaki Kubo,Yoshinori Murakami,Kazuhiko Yamamoto,Yoichiro Kamatani,Aarno Palotie,Aarno Palotie,Aarno Palotie,Manuel A. Rivas,Mark J. Daly,Koichi Matsuda,Yukinori Okada +49 more
TL;DR: In this paper, the authors conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records.
Journal ArticleDOI
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.
Yuta Kochi,Yukinori Okada,Akari Suzuki,Katsunori Ikari,Chikashi Terao,Atsushi Takahashi,Keiko Yamazaki,Naoya Hosono,Keiko Myouzen,Tatsuhiko Tsunoda,Naoyuki Kamatani,Tatsuya Furuichi,Shiro Ikegawa,Koichiro Ohmura,Tsuneyo Mimori,Fumihiko Matsuda,Takuji Iwamoto,Shigeki Momohara,Hisashi Yamanaka,Ryo Yamada,Michiaki Kubo,Yusuke Nakamura,Kazuhiko Yamamoto +22 more
TL;DR: The results suggest that CCR6 is critically involved in IL-17–driven autoimmunity in human diseases, and is associated with susceptibility to Graves' and Crohn's diseases.