K
Konstantinos Sidiropoulos
Researcher at European Bioinformatics Institute
Publications - 33
Citations - 7466
Konstantinos Sidiropoulos is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Mobile device & Decision support system. The author has an hindex of 10, co-authored 32 publications receiving 5249 citations. Previous affiliations of Konstantinos Sidiropoulos include Technological Educational Institute of Athens & Brunel University London.
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Journal ArticleDOI
The Reactome Pathway Knowledgebase.
Antonio Fabregat,Konstantinos Sidiropoulos,Phani V. Garapati,Marc Gillespie,Marc Gillespie,Kerstin Hausmann,Robin Haw,Bijay Jassal,S Jupe,Florian Korninger,Sheldon J. McKay,Lisa Matthews,Bruce May,Marija Milacic,Karen Rothfels,Veronica Shamovsky,Marissa Webber,Joel Weiser,Mark Williams,Guanming Wu,Lincoln Stein,Lincoln Stein,Lincoln Stein,Henning Hermjakob,Henning Hermjakob,Peter D'Eustachio +25 more
TL;DR: The Reactome Knowledgebase provides molecular details of signal transduction, transport, DNA replication, metabolism and other cellular processes as an ordered network of molecular transformations—an extended version of a classic metabolic map, in a single consistent data model.
Journal ArticleDOI
Reactome pathway analysis: a high-performance in-memory approach
Antonio Fabregat,Konstantinos Sidiropoulos,Guilherme Viteri,Oscar Forner,Pablo Marin-Garcia,Vicente Arnau,Peter D'Eustachio,Lincoln Stein,Lincoln Stein,Henning Hermjakob,Henning Hermjakob +10 more
TL;DR: Through the use of highly optimised, in-memory data structures and algorithms, Reactome has achieved a stable, high performance pathway analysis service, enabling the analysis of genome-wide datasets within seconds, allowing interactive exploration and analysis of high throughput data.
Journal ArticleDOI
The reactome pathway knowledgebase 2022.
Marc Gillespie,Marc Gillespie,Bijay Jassal,Ralf Stephan,Marija Milacic,Karen Rothfels,Andrea Senff-Ribeiro,Andrea Senff-Ribeiro,Johannes Griss,Johannes Griss,Cristoffer Sevilla,Lisa Matthews,Chuqiao Gong,Chuan Deng,Chuan Deng,Thawfeek M. Varusai,Eliot Ragueneau,Yusra Haider,Bruce May,Veronica Shamovsky,Joel Weiser,Timothy Brunson,Nasim Sanati,Liam Beckman,Xiang Shao,Antonio Fabregat,Konstantinos Sidiropoulos,Julieth Murillo,Guilherme Viteri,Justin Cook,Solomon Shorser,Gary D. Bader,Emek Demir,Chris Sander,Robin Haw,Guanming Wu,Lincoln Stein,Lincoln Stein,Henning Hermjakob,Henning Hermjakob,Peter D'Eustachio +40 more
TL;DR: The Reactome Knowledgebase as mentioned in this paper provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes, annotated as an ordered network of molecular transformations in a single consistent data model.
Journal ArticleDOI
Open Targets: a platform for therapeutic target identification and validation.
Gautier Koscielny,Peter An,Denise Carvalho-Silva,Jennifer A. Cham,Luca Fumis,Rippa Gasparyan,Samiul Hasan,Nikiforos Karamanis,Michael Maguire,Eliseo Papa,Andrea Pierleoni,Miguel Pignatelli,Theo Platt,Francis Rowland,Priyanka Wankar,A. Patrícia Bento,Tony Burdett,Antonio Fabregat,Simon A. Forbes,Anna Gaulton,Cristina Y. González,Henning Hermjakob,Anne Hersey,S Jupe,Senay Kafkas,Maria Keays,Catherine Leroy,Francisco-Javier Lopez,María Paula Magariños,James Malone,Johanna McEntyre,Alfonso Muñoz-Pomer Fuentes,Claire O'Donovan,Irene Papatheodorou,Helen Parkinson,Barbara Palka,Justin Paschall,Robert Petryszak,Naruemon Pratanwanich,Sirarat Sarntivijal,Gary Saunders,Konstantinos Sidiropoulos,Thomas Smith,Zbyslaw Sondka,Oliver Stegle,Y. Amy Tang,Edward Turner,Brendan Vaughan,Olga Vrousgou,Xavier Watkins,Maria Jesus Martin,Philippe Sanseau,Jessica Vamathevan,Ewan Birney,Jeffrey C. Barrett,Jeffrey C. Barrett,Ian Dunham +56 more
TL;DR: The Open Targets Validation Platform is designed to support identification and prioritization of biological targets for follow-up and provides evidence about the association of known and potential drug targets with diseases.
Journal ArticleDOI
Reactome graph database: Efficient access to complex pathway data.
Antonio Fabregat,Florian Korninger,Guilherme Viteri,Konstantinos Sidiropoulos,Pablo Marin-Garcia,Peipei Ping,Guanming Wu,Lincoln Stein,Lincoln Stein,Peter D'Eustachio,Henning Hermjakob,Henning Hermjakob +11 more
TL;DR: The Neo4j graph database and its query language, Cypher, provide efficient access to the complex Reactome data model, facilitating easy traversal and knowledge discovery and the Reactome graph database use case shows the power of NoSQL database engines for complex biological data types.