Karen Rothfels

TL;DR: The Reactome Knowledgebase provides molecular details of signal transduction, transport, DNA replication, metabolism and other cellular processes as an ordered network of molecular transformations—an extended version of a classic metabolic map, in a single consistent data model.

TL;DR: The Reactome Knowledgebase as mentioned in this paper provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes, annotated as an ordered network of molecular transformations in a single consistent data model.

TL;DR: Reactome describes biological pathways as chemical reactions that closely mirror the actual physical interactions that occur in the cell, and adapted the Pathway Browser to display disease variants and events in a way that allows comparison with the wild type pathway, and shows connections between perturbations in cancer and other biological pathways.

TL;DR: New developments in the Reactome visualization system are presented that facilitate navigation through the pathway hierarchy and enable efficient reuse of Reactome visualizations for users’ own research presentations and publications.

TL;DR: The development of the interactive task, from planning to execution, is described and major findings for the systems tested are discussed.