Maria Keays

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The main development over the last two years has been the release of a new data submission tool Annotare, which has reduced the average submission time almost 3-fold and will become the only submission route into ArrayExpress, alongside MAGE-TAB format-based pipelines in the near future.

TL;DR: The first proteomics study in human tissues is now displayed alongside transcriptomics data in the same tissues, and novel analyses and visualisations include: ‘enrichment’ in each differential comparison of GO terms, Reactome, Plant Reactome pathways and InterPro domains.

TL;DR: The ArrayExpress Archive of Functional Genomics Data ( ArrayExpress) is one of three international functional genomics public data repositories, alongside the Gene Expression Omnibus at NCBI and the DDBJ Omics Archive, supporting peer-reviewed publications.

TL;DR: The Open Targets Validation Platform is designed to support identification and prioritization of biological targets for follow-up and provides evidence about the association of known and potential drug targets with diseases.