K
Koshiro Monzen
Researcher at University of Tokyo
Publications - 29
Citations - 1871
Koshiro Monzen is an academic researcher from University of Tokyo. The author has contributed to research in topics: Transcription factor & Cellular differentiation. The author has an hindex of 18, co-authored 28 publications receiving 1792 citations.
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Journal ArticleDOI
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.
TL;DR: Using the yeast two-hybrid system with Nkx2-5 as the "bait", this article isolated the T-box-containing transcription factor Tbx5; mutations in TBX5 cause heart and limb malformations in Holt-Oram syndrome (HOS).
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Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
Koshiro Monzen,Ichiro Shiojima,Yukio Hiroi,Sumiyo Kudoh,Toru Oka,Eiki Takimoto,Doubun Hayashi,Toru Hosoda,Akemi Habara-Ohkubo,Takashi Nakaoka,Toshiro Fujita,Yoshio Yazaki,Issei Komuro +12 more
TL;DR: The results suggest that TAK1, Csx/Nkx-2.5, and GATA-4 play a pivotal role in the cardiogenic BMP signaling pathway.
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Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
Koshiro Monzen,Yukio Hiroi,Sumiyo Kudoh,Hiroshi Akazawa,Toru Oka,Eiki Takimoto,Doubun Hayashi,Toru Hosoda,Masahiro Kawabata,Kohei Miyazono,Shunsuke Ishii,Yoshio Yazaki,Ryozo Nagai,Issei Komuro +13 more
TL;DR: The results suggest that Smads, TAK1, and their common target ATF-2 cooperatively play a critical role in cardiomyocyte differentiation.
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Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
Ichiro Shiojima,Issei Komuro,Toru Oka,Yukio Hiroi,Takehiko Mizuno,Eiki Takimoto,Koshiro Monzen,Ryuichi Aikawa,Hiroshi Akazawa,Tsutomu Yamazaki,Sumiyo Kudoh,Yoshio Yazaki +11 more
TL;DR: Findings indicate that the cooperative transcriptional regulation mediated by Csx/Nkx-2.5 and GATA-4 is promoter context-dependent and suggest that the complexcis-trans interactions may fine-tune gene expression in cardiac myocytes.
Journal ArticleDOI
UTF1 is a chromatin-associated protein involved in ES cell differentiation
Vincent van den Boom,Susanne M. Kooistra,Marije Boesjes,Bart Geverts,Adriaan B. Houtsmuller,Koshiro Monzen,Issei Komuro,Jeroen Essers,Loes J. Drenth-Diephuis,Bart J. L. Eggen +9 more
TL;DR: It is reported that UTF1 (undifferentiated embryonic cell transcription factor 1) is involved in ES cell differentiation, and analysis using fluorescence recovery after photobleaching assays, subnuclear fractionations, and reporter assays revealed that it is a stably chromatin-associated transcriptional repressor protein with a dynamic behavior similar to core histones.