K
Kozo Kaibuchi
Researcher at Nagoya University
Publications - 508
Citations - 63012
Kozo Kaibuchi is an academic researcher from Nagoya University. The author has contributed to research in topics: Rho-associated protein kinase & Phosphorylation. The author has an hindex of 129, co-authored 493 publications receiving 60461 citations. Previous affiliations of Kozo Kaibuchi include Nara Institute of Science and Technology & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells
Yuko Katakami,Yuko Katakami,Kozo Kaibuchi,Kozo Kaibuchi,Makoto Sawamura,Makoto Sawamura,Yoshimi Takai,Yoshimi Takai,Yasutomi Nishizuka,Yasutomi Nishizuka +9 more
TL;DR: The simultaneous addition of OAG or TPA and A23187 synergistically enhanced histamine release from mast cells is suggestive that protein kinase C activation and Ca2+ mobilization play essential roles for this cellular response.
Journal ArticleDOI
Design and synthesis of Rho kinase inhibitors (I)
Atsuya Takami,Masayuki Iwakubo,Yuji Okada,Takehisa Kawata,Hideharu Odai,Nobuaki Takahashi,Kazutoshi Shindo,Kaname Kimura,Yoshimichi Tagami,Mika Miyake,Kayoko Fukushima,Masaki Inagaki,Mutsuki Amano,Kozo Kaibuchi,Hiroshi Iijima +14 more
TL;DR: Several structurally unrelated scaffolds of the RhoKinase inhibitor were designed using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho kinase to comprehensively understand and predict the structure-activity relationship of the inhibitors.
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Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Atsushi Enomoto,Naoya Asai,Takashi Namba,Yun Wang,Takuya Kato,Motoki Tanaka,Hitoshi Tatsumi,Shinichiro Taya,Daisuke Tsuboi,Keisuke Kuroda,Naoko Kaneko,Kazunobu Sawamoto,Rieko Miyamoto,Mayumi Jijiwa,Yoshiki Murakumo,Masahiro Sokabe,Tatsunori Seki,Tatsunori Seki,Kozo Kaibuchi,Masahide Takahashi +19 more
TL;DR: It is reported that DISC1 interacts with the actin-binding protein girdin to regulate axonal development and is identified as an intrinsic factor in postnatal development of the dentate gyrus and insights are provided into the critical role of the DISC 1/girdin interaction inPostnatal neurogenesis in the DG.
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Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3β/CRMP-2 pathway
TL;DR: The results suggest that Ras plays critical roles in establishing neuronal polarity upstream of the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway and mitogen-activated protein kinase cascade.
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Genome-wide association study of schizophrenia in a Japanese population.
Masashi Ikeda,Branko Aleksic,Branko Aleksic,Yoko Kinoshita,Tomo Okochi,Kunihiro Kawashima,Itaru Kushima,Itaru Kushima,Yoshihito Ito,Yoshihito Ito,Yukako Nakamura,Taro Kishi,Takenori Okumura,Yasuhisa Fukuo,Hywel Williams,Marian L. Hamshere,Dobril Ivanov,Toshiya Inada,Michio Suzuki,Ryota Hashimoto,Ryota Hashimoto,Hiroshi Ujike,Masatoshi Takeda,Masatoshi Takeda,Nicholas John Craddock,Kozo Kaibuchi,Michael John Owen,Norio Ozaki,Michael Conlon O'Donovan,Nakao Iwata +29 more
TL;DR: A shared polygenic risk of schizophrenia between Japanese and Caucasian samples is indicated, although the results did not detect unequivocal evidence for a novel susceptibility gene for schizophrenia.