K
Kristen R. Maynard
Researcher at Johns Hopkins University
Publications - 54
Citations - 1318
Kristen R. Maynard is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Neurotrophic factors & Biology. The author has an hindex of 12, co-authored 44 publications receiving 564 citations. Previous affiliations of Kristen R. Maynard include Bowdoin College & Yale University.
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Journal ArticleDOI
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.
Kristen R. Maynard,Leonardo Collado-Torres,Lukas M. Weber,Cedric Uytingco,Brianna K. Barry,Stephen R. Williams,Joseph L. Catallini,Matthew N. Tran,Zachary Besich,Madhavi Tippani,Jennifer Chew,Yifeng Yin,Joel E. Kleinman,Thomas M. Hyde,Nikhil Rao,Stephanie C. Hicks,Keri Martinowich,Andrew E. Jaffe +17 more
TL;DR: This article used the 10x Genomics Visium platform to define the spatial topography of gene expression in the six-layered human dorsolateral prefrontal cortex and identified extensive layer-enriched expression signatures and refined associations to previous laminar markers.
Journal ArticleDOI
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
Kristen R. Maynard,Leonardo Collado Torres,Lukas M. Weber,Cedric Uytingco,Brianna K. Barry,Stephen R. Williams,Joseph L. Catallini,Matthew N. Tran,Zachary Besich,Madhavi Tippani,Jennifer Chew,Yifeng Yin,Thomas M. Hyde,Nikhil Rao,Stephanie C. Hicks,Keri Martinowich,Andrew E. Jaffe +16 more
Journal ArticleDOI
Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling
Kristen R. Maynard,Julia L. Hill,Nicholas E. Calcaterra,Mary Ellen Palko,Alisha Kardian,Daniel Paredes,Mahima Sukumar,Benjamin D. Adler,Dennisse V. Jimenez,Robert J. Schloesser,Lino Tessarollo,Bai Lu,Keri Martinowich +12 more
TL;DR: In this paper, the authors generated four mutant mouse lines in which BDNF production from one of the four major promoters (I, II, IV, or VI) is selectively disrupted (Bdnf-e1, -e2, −e4, and −e6 mice).
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Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression
Robert J. Schloesser,Sophie Orvoen,Dennisse V. Jimenez,Nicholas F. Hardy,Kristen R. Maynard,Mahima Sukumar,Husseini K. Manji,Alain M. Gardier,Denis J. David,Keri Martinowich +9 more
TL;DR: ECS ameliorates a number of anxiety- and depressive-like behaviors caused by chronic exposure to CORT, and requires intact hippocampal neurogenesis for its efficacy in these behavioral indices.
Journal ArticleDOI
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.
Andrew E. Jaffe,Daniel J. Hoeppner,Daniel J. Hoeppner,Takeshi Saito,Lou Blanpain,Joy Ukaigwe,Emily E. Burke,Leonardo Collado-Torres,Ran Tao,Katsunori Tajinda,Kristen R. Maynard,Matthew N. Tran,Keri Martinowich,Amy Deep-Soboslay,Joo Heon Shin,Joel E. Kleinman,Daniel R. Weinberger,Mitsuyuki Matsumoto,Thomas M. Hyde +18 more
TL;DR: The granule cell layer of the human hippocampus is transcriptomically profile and unique molecular associations for aging and genetic variation, as well as diagnosis with schizophrenia and its genetic risk, that were previously undiscovered in homogenate tissue are found.