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Alain M. Gardier
Researcher at Université Paris-Saclay
Publications - 154
Citations - 9679
Alain M. Gardier is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Serotonin & Antidepressant. The author has an hindex of 51, co-authored 149 publications receiving 8731 citations. Previous affiliations of Alain M. Gardier include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression
Denis J. David,Benjamin Adam Samuels,Quentin Rainer,Jingwen Wang,Douglas Marsteller,Indira Mendez,Michael R. Drew,Douglas A. Craig,Bruno P. Guiard,Jean-Philippe Guilloux,Roman Artymyshyn,Alain M. Gardier,Christophe P. G. Gerald,Irina Antonijevic,E. David Leonardo,René Hen +15 more
TL;DR: A mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment is described, and mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-Arrestin signaling is necessary for the antidepressant effects of fluoxettine.
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Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors.
Uwe Maskos,B. E. Molles,Stéphanie Pons,Morgane Besson,Morgane Besson,Bruno P. Guiard,Jean-Philippe Guilloux,Alexis Evrard,Pierre Cazala,A. Cormier,Monica Mameli-Engvall,Noelle Dufour,Isabelle Cloëz-Tayarani,Alexis-Pierre Bemelmans,Jacques Mallet,Alain M. Gardier,Vincent David,Philippe Faure,Sylvie Granon,Jean-Pierre Changeux +19 more
TL;DR: The efficient re-expression of electrophysiologically responsive, ligand-binding nicotinic acetylcholine receptors in dopamine-containing neurons of the VTA is demonstrated, together with the recovery of nicotine-elicited dopamine release and nicotine self-administration.
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Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice
Nicolas Champtiaux,Cecilia Gotti,Matilde Cordero-Erausquin,Denis J. David,Cédric Przybylski,Clément Léna,Francesco Clementi,Milena Moretti,Francesco M. Rossi,Nicolas Le Novère,J. Michael McIntosh,Alain M. Gardier,Jean-Pierre Changeux +12 more
TL;DR: It is established that α6β2* nAChRs are functional and sensitive to α-conotoxin MII inhibition, and somato-dendritic (nonα6)α4β2- nA ChRs most likely contribute to nicotine reinforcement.
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5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
Jesse W. Richardson-Jones,Caryne Craige,Bruno P. Guiard,Alisson Stephen,Kayla L. Metzger,Hank F. Kung,Alain M. Gardier,Alex Dranovsky,Denis J. David,Sheryl G. Beck,René Hen,E. David Leonardo +11 more
TL;DR: A causal relationship between 5-HT(1A) autoreceptor levels, resilience under stress, and response to antidepressants is established.
Journal ArticleDOI
Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression.
Jean-Philippe Guilloux,Gaelle Douillard-Guilloux,Rama S. Kota,Xingbin Wang,Alain M. Gardier,Keri Martinowich,George C. Tseng,David A. Lewis,Etienne Sibille +8 more
TL;DR: Investigating putative mechanisms shows that this core MDD-related gene profile is recapitulated by complementary patterns in mice with constitutive or activity-dependent decreases in BDNF function, particularly affecting SST/NPY-related GABA neurons, thus linking the neurotrophic and GABA hypotheses of depression.