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Kristin M. Boulier
Publications - 11
Citations - 557
Kristin M. Boulier is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications receiving 432 citations.
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Journal ArticleDOI
Total Synthesis of a Functional Designer Eukaryotic Chromosome
Narayana Annaluru,Héloïse Muller,Leslie A. Mitchell,Sivaprakash Ramalingam,Giovanni Stracquadanio,Sarah M. Richardson,Jessica S. Dymond,Zheng Kuang,Lisa Z. Scheifele,Eric M. Cooper,Yizhi Cai,Karen I. Zeller,Neta Agmon,Jeffrey S. Han,Michalis Hadjithomas,Jennifer Tullman,Katrina Caravelli,Kimberly M. Cirelli,Zheyuan Guo,Viktoriya London,Apurva Yeluru,Sindurathy Murugan,Karthikeyan Kandavelou,Nicolas Agier,Nicolas Agier,Gilles Fischer,Gilles Fischer,Kun Yang,J. Andrew Martin,Murat Bilgel,Pavlo Bohutski,Kristin M. Boulier,Brian J. Capaldo,Joy Chang,Kristie Charoen,Woo Jin Choi,Peter Deng,James E. DiCarlo,Judy Doong,Jessilyn Dunn,Jason I. Feinberg,Christopher Fernandez,Charlotte E. Floria,David Gladowski,Pasha Hadidi,Isabel E. Ishizuka,Javaneh Jabbari,Calvin Y. L. Lau,Pablo A. Lee,Sean Li,Denise Lin,Matthias E. Linder,Jonathan P. Ling,Jaime Liu,Jonathan Liu,Mariya London,Henry Ma,Jessica Mao,Jessica E. McDade,Alexandra McMillan,Aaron M. Moore,Won Chan Oh,Yu Ouyang,Ruchi Patel,Marina Paul,Laura C. Paulsen,Judy Qiu,Alex Rhee,Matthew G. Rubashkin,Ina Y. Soh,Nathaniel E. Sotuyo,Venkatesh Srinivas,Allison Suarez,Andrew D. Wong,Remus S. Wong,Wei Xie,Yijie Xu,Allen T. Yu,Romain Koszul,Romain Koszul,Joel S. Bader,Jef D. Boeke,Srinivasan Chandrasegaran +82 more
TL;DR: SynIII as mentioned in this paper is a designer eukaryotic chromosome based on the S. cerevisiae chromosome III that includes TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites.
Journal ArticleDOI
Total synthesis of a functional designer eukaryotic chromosome (Science (2014) 344, 6179 (55-58))
Narayana Annaluru,Héloïse Muller,Leslie A. Mitchell,Sivaprakash Ramalingam,Giovanni Stracquadanio,Sarah M. Richardson,Jessica S. Dymond,Zheng Kuang,Lisa Z. Scheifele,Eric M. Cooper,Yizhi Cai,Karen I. Zeller,Neta Agmon,Jeffrey S. Han,Michalis Hadjithomas,Jennifer Tullman,Katrina Caravelli,Kimberly M. Cirelli,Zheyuan Guo,Viktoriya London,Apurva Yeluru,Sindurathy Murugan,Karthikeyan Kandavelou,Nicolas Agier,Gilles Fischer,Kun Yang,J. Andrew Martin,Murat Bilgel,Pavlo Bohutskyi,Kristin M. Boulier,Brian J. Capaldo,Joy Chang,Kristie Charoen,Woo Jin Choi,Peter Deng,James E. DiCarlo,Judy Doong,Jessilyn Dunn,Jason I. Feinberg,Christopher Fernandez,Charlotte E. Floria,David Gladowski,Pasha Hadidi,Isabel E. Ishizuka,Javaneh Jabbari,Calvin Y. L. Lau,Pablo A. Lee,Sean Li,Denise Lin,Matthias E. Linder,Jonathan P. Ling,Jaime Liu,Jonathan Liu,Mariya London,Henry Ma,Jessica Mao,Jessica E. McDade,Alexandra McMillan,Aaron M. Moore,Won Chan Oh,Yu Ouyang,Ruchi Patel,Marina Paul,Laura C. Paulsen,Judy Qiu,Alex Rhee,Matthew G. Rubashkin,Ina Y. Soh,Nathaniel E. Sotuyo,Venkatesh Srinivas,Allison Suarez,Andrew D. Wong,Remus S. Wong,Wei Xie,Yijie Xu,Allen T. Yu,Romain Koszul,Joel S. Bader,Jef D. Boeke,Srinivasan Chandrasegaran +79 more
Journal ArticleDOI
Polygenic scoring accuracy varies across the genetic ancestry continuum
Yi Ding,Kangcheng Hou,Ziqi Xu,Aditya Pimplaskar,Ella Petter,Kristin M. Boulier,Florian Privé,Bjarni J. Vilhjálmsson,Loes M. Olde Loohuis,Bogdan Pasaniuc +9 more
TL;DR: In this paper , the authors show that PGS accuracy decreases individual-to-individual along the continuum of genetic ancestries in all considered populations, even within traditionally labelled 'homogeneous' genetic ancestry.
Journal ArticleDOI
Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative
Ruth E. Johnson,Yi Ding,Vidhya Venkateswaran,Arjun Bhattacharya,Kristin M. Boulier,Alec M. Chiu,Sergey Knyazev,Tommer Schwarz,Malika K. Freund,Lingyu Zhan,Kathryn S. Burch,Christa Caggiano,Brian L. Hill,Nadav Rakocz,Brunilda Balliu,Christopher T. Denny,Jae Hoon Sul,Noah Zaitlen,Valerie A. Arboleda,Eran Halperin,Sriram Sankararaman,Manish J. Butte,Clara Lajonchere,Daniel H. Geschwind,Bogdan Pasaniuc +24 more
TL;DR: In this article , the implications of genetic ancestry within the University of California, Los Angeles (UCLA) ATLAS Community Health Initiative (ATLAS) data were explored using principal component analysis, identity-by-descent, and genetic admixture.
Journal ArticleDOI
Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative
Ruth E. Johnson,Yi Ding,Vidhya Venkateswaran,Arjun Bhattacharya,Kristin M. Boulier,Alec M. Chiu,Sergey Knyazev,Tommer Schwarz,Malika K. Freund,Lingyu Zhan,Kathryn S. Burch,Christa Caggiano,Brian L. Hill,Nadav Rakocz,Brunilda Balliu,Christopher T. Denny,Jae Hoon Sul,Noah Zaitlen,Valerie A. Arboleda,Eran Halperin,Sriram Sankararaman,Manish J. Butte,Clara Lajonchere,Daniel H. Geschwind,Bogdan Pasaniuc +24 more
TL;DR: In this article , the implications of genetic ancestry within the University of California, Los Angeles (UCLA) ATLAS Community Health Initiative (ATLAS) data were explored using principal component analysis, identity-by-descent, and genetic admixture.