K
Kristine R. Crews
Researcher at St. Jude Children's Research Hospital
Publications - 122
Citations - 6571
Kristine R. Crews is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Irinotecan & Leukemia. The author has an hindex of 38, co-authored 107 publications receiving 5483 citations. Previous affiliations of Kristine R. Crews include Baylor College of Medicine & University of Tennessee Health Science Center.
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Journal ArticleDOI
Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
Kristine R. Crews,Andrea Gaedigk,Andrea Gaedigk,Henry M. Dunnenberger,J. S. Leeder,J. S. Leeder,Teri E. Klein,Kelly E. Caudle,Cyrine E. Haidar,Danny D. Shen,J T Callaghan,J T Callaghan,Senthilkumar Sadhasivam,Cynthia A. Prows,Evan D. Kharasch,Todd C. Skaar +15 more
TL;DR: This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy and provides therapeutic recommendations for codeine based on CYP1D8 genotype.
Journal ArticleDOI
Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers
Henry M. Dunnenberger,Kristine R. Crews,James M. Hoffman,Kelly E. Caudle,Ulrich Broeckel,Scott C. Howard,Robert J. Hunkler,Teri E. Klein,William E. Evans,Mary V. Relling +9 more
TL;DR: Current programs that use preemptive genotyping to optimize the pharmacotherapy of patients are discussed and key processes for implementation are highlighted, including clinical decision support.
Journal ArticleDOI
Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
Jun J. Yang,Wendy Landier,Wenjian Yang,Chengcheng Liu,Lindsey Hageman,Cheng Cheng,Deqing Pei,Yanjun Chen,Kristine R. Crews,Nancy Kornegay,F. Lennie Wong,William E. Evans,Ching-Hon Pui,Smita Bhatia,Mary V. Relling +14 more
TL;DR: A germline variant in NUDT15 strongly associated with MP intolerance in childhood ALL is described, which may have implications for treatment individualization in this disease.
Journal ArticleDOI
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
Kristine R. Crews,Andrea Gaedigk,Henry M. Dunnenberger,Teri E. Klein,Danny D. Shen,J T Callaghan,J T Callaghan,Evan D. Kharasch,Todd C. Skaar +8 more
TL;DR: This guideline is to provide information relating to the interpretation of CYP2D6 genotype test results to guide the dosing of codeine.
Journal ArticleDOI
Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process
Kelly E. Caudle,Teri E. Klein,James M. Hoffman,Daniel J. Müller,Michelle Whirl-Carrillo,Li Gong,Ellen M. McDonagh,Katrin Sangkuhl,Caroline F. Thorn,Matthias Schwab,Matthias Schwab,José A. G. Agúndez,Robert R. Freimuth,Vojtech Huser,Ming Ta Michael Lee,Ming Ta Michael Lee,Otito F. Iwuchukwu,Kristine R. Crews,Stuart A. Scott,Mia Wadelius,Jesse J. Swen,Rachel F. Tyndale,C. Michael Stein,Dan M. Roden,Mary V. Relling,Marc S. Williams,Samuel G. Johnson +26 more
TL;DR: This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines.