K
Kun Zhang
Researcher at Chinese Academy of Sciences
Publications - 11
Citations - 884
Kun Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Proteome & Proteogenomics. The author has an hindex of 8, co-authored 11 publications receiving 754 citations.
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Journal ArticleDOI
Identification of cross-linked peptides from complex samples
Bing Yang,Yan-Jie Wu,Ming Zhu,Sheng-Bo Fan,Jinzhong Lin,Kun Zhang,Shuang Li,Hao Chi,Yu-Xin Li,Hai-Feng Chen,Shukun Luo,Yue-He Ding,Le-Heng Wang,Zhiqi Hao,Li-Yun Xiu,She Chen,Keqiong Ye,Si-Min He,Meng-Qiu Dong +18 more
TL;DR: pLink as mentioned in this paper is a software for data analysis of cross-linked proteins coupled with mass-spectrometry analysis, which is compatible with multiple homo- or hetero-bifunctional cross-linkers.
Journal ArticleDOI
Mapping native disulfide bonds at a proteome scale
Shan Lu,Sheng-Bo Fan,Bing Yang,Yu-Xin Li,Jia-Ming Meng,Long Wu,Pin Li,Kun Zhang,Mei-Jun Zhang,Yan Fu,Jincai Luo,Rui-Xiang Sun,Si-Min He,Meng-Qiu Dong +13 more
TL;DR: Using pLink-SS, a high-throughput mass spectrometry method, all native disulfide bonds of a monoclonal antibody and ten standard proteins are mapped and many regulatory disulfides involving catalytic or metal-binding cysteine residues are discovered.
Journal ArticleDOI
pQuant improves quantitation by keeping out interfering signals and evaluating the accuracy of calculated ratios.
Chao Liu,Chun-Qing Song,Zuo-Fei Yuan,Yan Fu,Hao Chi,Le-Heng Wang,Sheng-Bo Fan,Kun Zhang,Wen-Feng Zeng,Si-Min He,Meng-Qiu Dong,Rui-Xiang Sun +11 more
TL;DR: Results show that pQuant outperforms Census and MaxQuant in SILAC and (15)N-based quantitation, and estimates the protein ratios and associated CIs by kernel density estimation.
Journal ArticleDOI
pFind-Alioth: A novel unrestricted database search algorithm to improve the interpretation of high-resolution MS/MS data.
Hao Chi,Kun He,Bing Yang,Zhen Chen,Rui-Xiang Sun,Sheng-Bo Fan,Kun Zhang,Chao Liu,Zuo-Fei Yuan,Quanhui Wang,Siqi Liu,Meng-Qiu Dong,Si-Min He +12 more
TL;DR: A new algorithm called Alioth, to be integrated into the search engine of pFind, for fast and accurate unrestricted database search on high-resolution MS/MS data, and is comparable to or even faster than the restricted search algorithms tested.
Journal ArticleDOI
Using pLink to Analyze Cross-Linked Peptides
Sheng-Bo Fan,Jia-Ming Meng,Shan Lu,Kun Zhang,Hao Yang,Hao Chi,Rui-Xiang Sun,Meng-Qiu Dong,Si-Min He +8 more
TL;DR: Detailed guidance on running a database search for identification of protein cross‐links using the 2014 version of pLink is provided, which is at least 40 times faster, more versatile, and more user‐friendly.