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Kunihiko Hinohara
Researcher at Harvard University
Publications - 39
Citations - 2399
Kunihiko Hinohara is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Epigenetics. The author has an hindex of 21, co-authored 33 publications receiving 1772 citations. Previous affiliations of Kunihiko Hinohara include Nagoya University & Tokyo Medical and Dental University.
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Journal ArticleDOI
Genetic and transcriptional evolution alters cancer cell line drug response
Uri Ben-David,Benjamin A. Siranosian,Gavin Ha,Gavin Ha,Helen Tang,Yaara Oren,Yaara Oren,Kunihiko Hinohara,Kunihiko Hinohara,Craig A. Strathdee,Joshua M. Dempster,Nicholas J. Lyons,Robert Burns,Anwesha Nag,Guillaume Kugener,Beth A. Cimini,Peter Tsvetkov,Yosef E. Maruvka,Ryan O’Rourke,Ryan O’Rourke,Anthony J. Garrity,Andrew A. Tubelli,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Aviad Tsherniak,Francisca Vazquez,Bang Wong,Chet Birger,Mahmoud Ghandi,Aaron R. Thorner,Joshua A. Bittker,Matthew Meyerson,Matthew Meyerson,Gad Getz,Gad Getz,Rameen Beroukhim,Todd R. Golub +36 more
TL;DR: The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
Journal ArticleDOI
KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance
Kunihiko Hinohara,Hua-Jun Wu,Sébastien Vigneau,Thomas O. McDonald,Kyomi J. Igarashi,Kimiyo N. Yamamoto,Thomas Madsen,Anne Fassl,Shawn Egri,Malvina Papanastasiou,Lina Ding,Guillermo Peluffo,Ofir Cohen,Stephen C. Kales,Madhu Lal-Nag,Ganesha Rai,David J. Maloney,Ajit Jadhav,Anton Simeonov,Nikhil Wagle,Myles Brown,Alexander Meissner,Piotr Sicinski,Jacob D. Jaffe,Rinath Jeselsohn,Alexander A. Gimelbrant,Franziska Michor,Kornelia Polyak +27 more
TL;DR: It is shown that genetic deletion of KDM5A/B or inhibition of K DM5 activity increases sensitivity to anti-estrogens by modulating estrogen receptor (ER) signaling and by decreasing cellular transcriptomic heterogeneity.
Journal ArticleDOI
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
Kunihiko Hinohara,Toshiaki Nakajima,Megumi Takahashi,Shigeru Hohda,Taishi Sasaoka,Ken-ichi Nakahara,Kouji Chida,Motoji Sawabe,Takuro Arimura,Akinori Sato,Bok-Soo Lee,Jimin Ban,Michio Yasunami,Jeong-Euy Park,Toru Izumi,Akinori Kimura +15 more
TL;DR: It is demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians, and in both Japanese and Koreans.
Journal ArticleDOI
Intratumoral Heterogeneity: More Than Just Mutations
TL;DR: The therapeutic targeting of epigenetic enzymes may be used to decrease intratumoral cellular heterogeneity and treatment resistance, when used in combination with other types of agents.
Journal ArticleDOI
MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer.
Takahiro Maeda,Masayuki Hiraki,Caining Jin,Hasan Rajabi,Ashujit Tagde,Maroof Alam,Audrey Bouillez,Xiufeng Hu,Yozo Suzuki,Masaaki Miyo,Tsuyoshi Hata,Kunihiko Hinohara,Donald Kufe +12 more
TL;DR: It is reported that genetic or pharmacological targeting of the oncogenic M UC1 subunit MUC1-C is sufficient to suppress PD-L1 expression in TNBC cells, and this finding offers a rationale to target MUC-C as a novel immunotherapeutic approach for TNBC treatment.