K
Kurt Tobler
Researcher at University of Zurich
Publications - 71
Citations - 2148
Kurt Tobler is an academic researcher from University of Zurich. The author has contributed to research in topics: Virus & Gene. The author has an hindex of 23, co-authored 70 publications receiving 1890 citations. Previous affiliations of Kurt Tobler include Northwestern University.
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Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence.
TL;DR: Comparative amino acid sequence alignments revealed that PEDV is most closely related to human coronavirus (HCoV)-229E and transmissible gastroenteritis virus (TGEV) and less related to murine hepatitis virus (MHV), and infectious bronchitis virus(IBV).
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Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli : rescue of replication-competent virus progeny and packaging of amplicon vectors
Yoshinaga Saeki,Tomotsuga Ichikawa,A Saeki,E A Chiocca,Kurt Tobler,Kurt Tobler,Mathias Ackermann,Xandra O. Breakefield,Cornel Fraefel,Cornel Fraefel +9 more
TL;DR: The capacity of generating infectious and replication-competent HSV-1 progeny following transfection into mammalian cells was restored after insertion of a pac signal into fHSV delta pac, and the resulting amplicon stocks are virtually free of contaminating helper virus.
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Sequence Analysis of the Porcine Epidemic Diarrhea Virus Genome between the Nucleocapsid and Spike Protein Genes Reveals a Polymorphic ORF
TL;DR: In this paper, cDNA clones covering the region between the nucleocapsid and the spike (S) protein genes were independently constructed and sequenced for the two virulent isolates Br1/87 and CV777.
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Impairment of Nuclear Pores in Bovine Herpesvirus 1-Infected MDBK Cells
Peter J. Wild,Monika Engels,Claudia Senn,Kurt Tobler,Urs Ziegler,Elisabeth M. Schraner,Eva Loepfe,Mathias Ackermann,Martin Mueller,Paul Walther +9 more
TL;DR: High-resolution scanning and transmission electron microscopy proved the distortions to be related to enlargement of nuclear pores through which nuclear content including capsids protrudes into the cytoplasm, suggesting that capsid-membrane interaction of high identity to the budding process at the inner nuclear membrane.
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Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus
TL;DR: The nucleotide sequence of 1.7 kbp cDNA, comprising the region nearest the 3' end of the genome of the porcine epidemic diarrhoea virus (PEDV), has been independently determined for two European isolates of PEDV, and results confirm the earlier provisional classification of P EDV as a coronavirus.