L
Lawrence H. Smith
Researcher at National Institutes of Health
Publications - 15
Citations - 2129
Lawrence H. Smith is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene expression profiling & Gene expression. The author has an hindex of 11, co-authored 15 publications receiving 2094 citations.
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Journal ArticleDOI
A gene expression database for the molecular pharmacology of cancer
Uwe Scherf,Douglas T. Ross,Mark Waltham,Lawrence H. Smith,Jae K. Lee,Lorraine K. Tanabe,Kurt W. Kohn,William C. Reinhold,Timothy G. Myers,Darren T. Andrews,Dominic A. Scudiero,Michael B. Eisen,Edward A. Sausville,Yves Pommier,David Botstein,Patrick O. Brown,John N. Weinstein +16 more
TL;DR: Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance.
Journal ArticleDOI
MedMiner: an Internet text-mining tool for biomedical information, with application to gene expression profiling.
Lorraine K. Tanabe,Uwe Scherf,Lawrence H. Smith,Jae K. Lee,Lawrence Hunter,Lawrence Hunter,John N. Weinstein +6 more
TL;DR: An Internet-based hypertext program, MedMiner, which filters and organizes large amounts of textual and structured information returned from public search engines like GeneCards and PubMed, and can be used to organize the information returning from any arbitrary PubMed search.
Journal Article
Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage: microarray analysis of dose- and time-dependent effects.
Yi Zhou,Fuad G. Gwadry,William C. Reinhold,Lance D. Miller,Lawrence H. Smith,Uwe Scherf,Edison T. Liu,Kurt W. Kohn,Yves Pommier,John N. Weinstein +9 more
TL;DR: A fundamental difference at the gene expression level is suggested between the molecular mechanism of reversible G(2) delay that follows mild DNA damage and the mechanism of permanent G( 2) arrest that follows more extensive DNA damage.
Journal ArticleDOI
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
Jae K. Lee,Jae K. Lee,Kimberly J. Bussey,Fuad G. Gwadry,William C. Reinhold,Gregory Riddick,Sandra L. Pelletier,Satoshi Nishizuka,Gergely Szakács,Jean Phillipe Annereau,Uma Shankavaram,Samir Lababidi,Lawrence H. Smith,Michael M. Gottesman,John N. Weinstein +14 more
TL;DR: The result described here for the NCI-60 cancer cell lines is a consensus set of genes that give similar profiles on spotted cDNA arrays and Affymetrix oligonucleotide chips.
Proceedings Article
Fusion of knowledge-intensive and statistical approaches for retrieving and annotating textual genomics documents
Alan R. Aronson,Dina Demner-Fushman,Dina Demner-Fushman,Susanne M. Humphrey,Jimmy Lin,Jimmy Lin,Hongfang Liu,Patrick Ruch,Miguel E. Ruiz,Lawrence H. Smith,Lorraine K. Tanabe,W. John Wilbur +11 more
TL;DR: The results show that fusion approaches can improve the final outcome for the ad hoc and the categorization tasks, but that care must be taken in order to take advantage of the strengths of the constituent methods.