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Pamela Basto
Researcher at Stanford University
Publications - 44
Citations - 3326
Pamela Basto is an academic researcher from Stanford University. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 17, co-authored 43 publications receiving 2904 citations. Previous affiliations of Pamela Basto include Baylor College of Medicine & Brigham and Women's Hospital.
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Journal ArticleDOI
Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Rohit Karnik,Frank X. Gu,Pamela Basto,Christopher Cannizzaro,Lindsey Dean,William Kyei-Manu,Robert Langer,Omid C. Farokhzad +7 more
TL;DR: This work used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery.
Journal ArticleDOI
A vector-free microfluidic platform for intracellular delivery
Armon Sharei,Janeta Zoldan,Andrea Adamo,Woo Young Sim,Nahyun Cho,Emily L. Jackson,Shirley Mao,Sabine Schneider,Min-Joon Han,Abigail K. R. Lytton-Jean,Pamela Basto,Siddharth Jhunjhunwala,Jungmin Lee,Daniel A. Heller,Jeon Woong Kang,George C. Hartoularos,Kwang-Soo Kim,Daniel G. Anderson,Robert Langer,Klavs F. Jensen +19 more
TL;DR: A microfluidic approach to delivery in which cells are mechanically deformed as they pass through a constriction 30–80% smaller than the cell diameter results in the formation of transient holes that enable the diffusion of material from the surrounding buffer into the cytosol.
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Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing.
Pedro M. Valencia,Pamela Basto,Liangfang Zhang,Minsoung Rhee,Minsoung Rhee,Robert Langer,Omid C. Farokhzad,Omid C. Farokhzad,Rohit Karnik +8 more
TL;DR: The use of microfluidic rapid mixing using hydrodynamic flow focusing in combination with passive mixing structures to realize the self-assembly of monodisperse lipid-polymer and lipid-quantum dot NPs in a single mixing step is reported.
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A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
Georg Stary,Andrew J. Olive,Aleksandar F. Radovic-Moreno,David C. Gondek,David Alvarez,Pamela Basto,Mario Perro,Vladimir Vrbanac,Andrew M. Tager,Jinjun Shi,Jeremy Yethon,Omid C. Farokhzad,Omid C. Farokhzad,Robert Langer,Michael N. Starnbach,Ulrich H. von Andrian,Ulrich H. von Andrian +16 more
TL;DR: In this article, the authors show that UV-caused chlamydia trachomatis infection induces a long-lived protection in conventional and humanized mice, using charge switching synthetic adjuvant particles (cSAPs).
Journal ArticleDOI
Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle–Aptamer Bioconjugates
Liangfang Zhang,Aleksandar Filip Radovic-Moreno,Frank Alexis,Frank X. Gu,Pamela Basto,Vaishali Bagalkot,Sangyong Jon,Robert Langer,Omid C. Farokhzad +8 more
TL;DR: A promising application of surface-modification of NPs with antibodies, nucleic acid ligands, peptides, or small mole-cules that bind to antigens present on the target cells or tis-sues is proposed.