K
Kyle P. Carter
Researcher at University of Colorado Boulder
Publications - 13
Citations - 2242
Kyle P. Carter is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Metathesis & Lewis acids and bases. The author has an hindex of 8, co-authored 13 publications receiving 1803 citations. Previous affiliations of Kyle P. Carter include Western Washington University.
Papers
More filters
Journal ArticleDOI
Fluorescent Sensors for Measuring Metal Ions in Living Systems
Journal ArticleDOI
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Jing Li,Tanya R. Yakushi,Francesco Parlati,Andrew L. Mackinnon,Christian Perez,Yuyong Ma,Kyle P. Carter,Sharon A. Colayco,Gavin Magnuson,Brock T. Brown,Kevin Nguyen,Stefan Vasile,Eigo Suyama,Layton H. Smith,Eduard Sergienko,Anthony B. Pinkerton,Thomas D.Y. Chung,Amy E. Palmer,Ian Pass,Sonja Hess,Seth M. Cohen,Raymond J. Deshaies +21 more
TL;DR: Identification of capzimin offers an alternative path to develop proteasome inhibitors for cancer therapy and shows >5-fold selectivity for Rpn11 over the related JAMM proteases and >2 logs selectivity over several other metalloenzymes.
Journal ArticleDOI
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
Linda Lauinger,Jing Li,Anton Shostak,Ibrahim Avi Cemel,Nati Ha,Yaru Zhang,Philipp Merkl,Simon Obermeyer,Nicolas Stankovic-Valentin,Tobias Schafmeier,Walter Wever,Albert A. Bowers,Kyle P. Carter,Amy E. Palmer,Herbert Tschochner,Frauke Melchior,Raymond J. Deshaies,Michael Brunner,Axel Diernfellner +18 more
TL;DR: Reduced thiolutin is a zinc chelator that inhibits the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease Rpn11, a deubiquitinating enzyme of the 19S proteasome.
Journal ArticleDOI
Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors
Brett L. Fiedler,Steven Van Buskirk,Kyle P. Carter,Yan Qin,Yan Qin,Margaret C. Carpenter,Amy E. Palmer,Ralph Jimenez +7 more
TL;DR: A droplet microfluidic platform for the screening and separation of cell populations on the basis of the in vivo response of expressed fluorescence-based biosensors after addition of an exogenous analyte is developed.
Journal ArticleDOI
Discovery of a ZIP7 inhibitor from a Notch pathway screen.
Erin Nolin,Sara Gans,Luis Llamas,Somnath Bandyopadhyay,Scott M. Brittain,Paula Bernasconi-Elias,Kyle P. Carter,Joseph Loureiro,Jason R. Thomas,Markus Schirle,Yi Yang,Ning Guo,Guglielmo Roma,Sven Schuierer,Martin Beibel,Alicia Lindeman,Frederic Sigoillot,Amy Chen,Kevin Xie,Samuel B. Ho,John S. Reece-Hoyes,Wilhelm A. Weihofen,Kayla Tyskiewicz,Dominic Hoepfner,Richard I. McDonald,Nicolette Guthrie,Abhishek Dogra,Haibing Guo,Jian Shao,Jian Ding,Stephen M. Canham,Geoff Boynton,Elizabeth George,Zhao B. Kang,Christophe Antczak,Jeffery A. Porter,Owen Wallace,John A. Tallarico,Amy E. Palmer,Jeremy L. Jenkins,Rishi K. Jain,Bushell Simon,Christy Fryer +42 more
TL;DR: A cell-based phenotypic screen identifying inhibitors of Notch signaling led to the discovery of NVS-ZP7-4, which blocks the activity of the zinc transporter SLC39a7 (ZIP7) and induces cell death through an ER stress mechanism.