Kyung-Sup Kim

TL;DR: The development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes led to the development of high-performance Nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.

TL;DR: This study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.

TL;DR: In this article, a recombinant adeno-associated virus (rAAV) was used to produce a single-chain insulin analogue (SIA), which possesses biologically active insulin activity without enzymatic conversion, under the control of hepatocyte-specific L-type pyruvate kinase (LPK) promoter, which regulates SIA expression in response to blood glucose levels.

TL;DR: It is demonstrated that in normal mice, hypothalamic Foxo1 expression is reduced by the anorexigenic hormones insulin and leptin, establishing a new signaling pathway through which insulin andptin regulate food intake in hypothalamic neurons.

TL;DR: It is suggested that the expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both SRE BP-1 and SREBP-2 can transcriptionally activate PCSK 9 via SRE in its proximal promoter region in vitro.