Min-Seon Kim

TL;DR: It is reported that α-lipoic acid (α-LA), a cofactor of mitochondrial enzymes, decreases hypothalamic AMPK activity and causes profound weight loss in rodents by reducing food intake and enhancing energy expenditure.

TL;DR: Results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.

TL;DR: It is demonstrated that in normal mice, hypothalamic Foxo1 expression is reduced by the anorexigenic hormones insulin and leptin, establishing a new signaling pathway through which insulin andptin regulate food intake in hypothalamic neurons.

TL;DR: Mitochondrial function is linked to adiponectin synthesis in adipocytes, and mitochondrial dysfunction in adipose tissue may explain decreased plasma adiponECTin levels in obesity.

TL;DR: The results suggest that ALA-induced improvement of insulin sensitivity is mediated by activation of AMPK and reduced triglyceride accumulation in skeletal muscle.