Journal ArticleDOI
Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging
Young-wook Jun,Yong Min Huh,Jin Sil Choi,Jae Hyun Lee,Ho Taek Song,Sungjun Kim,Sarah Yoon,Kyung-Sup Kim,Jeon Soo Shin,Jin Suck Suh,Jinwoo Cheon +10 more
TLDR
The development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes led to the development of high-performance Nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.Abstract:
Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal−antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.read more
Citations
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Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
TL;DR: Practical Interests of Magnetic NuclearRelaxation for the Characterization of Superparamagnetic Colloid, and Use of Nanoparticles as Contrast Agents forMRI20825.
Journal ArticleDOI
Magnetic Nanoparticles in MR Imaging and Drug Delivery
TL;DR: A background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research are provided.
Journal ArticleDOI
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.
Jae Hyun Lee,Yong Min Huh,Young-wook Jun,Jung Wook Seo,Jung Tak Jang,Ho Taek Song,Sungjun Kim,Eun Jin Cho,Ho-Geun Yoon,Jin Suck Suh,Jinwoo Cheon +10 more
TL;DR: These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available and could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
Journal ArticleDOI
Synthesis of monodisperse spherical nanocrystals.
TL;DR: Mechanistic studies have shown that monodisperse nanocrystals are produced when the burst of nucleation that enables separation of the nucleation and growth processes is combined with the subsequent diffusion-controlled growth process through which the crystal size is determined.
Journal ArticleDOI
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Monty Liong,Jie Lu,Michael Kovochich,Tian Xia,Stefan G. Ruehm,Andre E. Nel,Fuyuhiko Tamanoi,Jeffrey I. Zink +7 more
TL;DR: In this article, superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation.
References
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Semiconductor Clusters, Nanocrystals, and Quantum Dots
TL;DR: In this article, the authors focus on the properties of quantum dots and their ability to join the dots into complex assemblies creates many opportunities for scientific discovery, such as the ability of joining the dots to complex assemblies.
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Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites
TL;DR: In this paper, a simple route to the production of high-quality CdE (E=S, Se, Te) semiconductor nanocrystallites is presented, based on pyrolysis of organometallic reagents by injection into a hot coordinating solvent.
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Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.
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Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Shouheng Sun,Hao Zeng,David B. Robinson,Simone Raoux,Philip M. Rice,Shan X. Wang,Guanxiong Li +6 more
TL;DR: As-synthesized iron oxide nanoparticles have a cubic spinel structure as characterized by HRTEM, SAED, and XRD and can be transformed into hydrophilic ones by adding bipolar surfactants, and aqueous nanoparticle dispersion is readily made.
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The use of nanocrystals in biological detection
TL;DR: The emerging ability to control the patterns of matter on the nanometer length scale can be expected to lead to entirely new types of biological sensors capable of sensing at the single-molecule level in living cells, and capable of parallel integration for detection of multiple signals.