Bernard Ferrier

TL;DR: mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.

TL;DR: These data provide the first demonstration in an animal model that renal gluconeogenesis is upregulated by a long-term mechanism during type 2 diabetes and lend support to the view so far based only on in vivo studies performed in humans that kidneys may be stimulated by and crucially contribute to the hyperglycemia of type 1 diabetes.

TL;DR: The results demonstrate that the abnormalities of muscle energy metabolism observed in patients with chronic renal failure are due, at least in part, to intrinsic changes in the key enzymes of major energy-providing pathways; they offer a satisfactory explanation for the defect of oxidative metabolism recently demonstrated in the muscle of these patients.

TL;DR: The results strongly suggest that, in the mouse kidney, glutamine synthetase is an important regulatory component of the availability of the ammonium ions to be excreted for defending systemic acid-base balance.

TL;DR: Calculation on the basis of fiber length, rather than dry weight, gave an estimate of absolute enzyme changes: hexokinase was still calculated to have increased in both soleus and TA fibers, but only by 50 and 25%, respectively.