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Aurelia Defour
Researcher at Aix-Marseille University
Publications - 20
Citations - 1404
Aurelia Defour is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Myocyte & Skeletal muscle. The author has an hindex of 15, co-authored 20 publications receiving 1116 citations. Previous affiliations of Aurelia Defour include University of Lyon & Jean Monnet University.
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Journal ArticleDOI
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
Valérie Risson,Laetitia Mazelin,Mila Roceri,Hervé Sanchez,Vincent Moncollin,Claudine Corneloup,Hélène Richard-Bulteau,Alban Vignaud,Dominique Baas,Aurelia Defour,Damien Freyssenet,Jean-François Tanti,Jean-François Tanti,Yannick Le-Marchand-Brustel,Yannick Le-Marchand-Brustel,Bernard Ferrier,Agnès Conjard-Duplany,Klaas Romanino,S. Bauche,Daniel Hantaï,Matthias Mueller,Sara C. Kozma,George Thomas,Markus A. Rüegg,Arnaud Ferry,Mario Pende,Xavier Bigard,Nathalie Koulmann,Laurent Schaeffer,Yann-Gaël Gangloff +29 more
TL;DR: mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.
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Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair.
Luana Scheffer,Sen Chandra Sreetama,Nimisha Sharma,Sushma Medikayala,Kristy J. Brown,Aurelia Defour,Jyoti K. Jaiswal +6 more
TL;DR: Ca2+-dependent accumulation of ESCRTIII-Vps4 complex following large focal injury to the cell membrane is demonstrated and the role of ALG-2 is identified as the initiator of sequential ESCRT III-VPS4 complex assembly that facilitates scission and repair of the injured cell membrane.
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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
François Bertrand Favier,Frédéric Costes,Aurelia Defour,Régis Bonnefoy,Etienne Lefai,Stéphane Baugé,André Peinnequin,H. Benoit,Damien Freyssenet +8 more
TL;DR: RedD1 is identified as a negative regulator of skeletal muscle mass during chronic hypoxia and Translation of this fundamental knowledge into the clinical investigation of COPD shows the interest to develop therapeutic strategies aimed at inhibiting REDD1.
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Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy
Maria Candida Vila,Maria Candida Vila,Sree Rayavarapu,Marshall W. Hogarth,Jack H. Van der Meulen,Adam Horn,Adam Horn,Aurelia Defour,Shin'ichi Takeda,Kristy J. Brown,Kristy J. Brown,Yetrib Hathout,Yetrib Hathout,Kanneboyina Nagaraju,Kanneboyina Nagaraju,Jyoti K. Jaiswal,Jyoti K. Jaiswal +16 more
TL;DR: It is identified that mitochondrial deficit in muscular dystrophy compromises the repair of injured myofibers and it is shown that this repair mechanism is distinct from and complimentary to the dysferlin-mediated repair of damaged myofiber cells.
Journal ArticleDOI
Mitochondrial redox signaling enables repair of injured skeletal muscle cells
Adam Horn,Jack H. Van der Meulen,Aurelia Defour,Marshall W. Hogarth,Sen Chandra Sreetama,Aaron Reed,Luana Scheffer,Navdeep S. Chandel,Jyoti K. Jaiswal +8 more
TL;DR: A physiological role for mitochondria is suggested in plasma membrane repair in injured cells, a role that highlights a beneficial effect of ROS.