Lara Cutlar

TL;DR: The findings prove that the A2 + B3 + C2 approach is highly generalizable and flexible for the design and synthesis of HPAEs, which cannot be achieved by the conventional polymerization approach; H PAEs are more efficient vectors in gene transfection than the corresponding LPAEs.

TL;DR: A series of hyperbranched poly(β-amino ester) polymers have been synthesized via a Michael addition approach for the fabrication of hydrogels for wound healing.

TL;DR: The development of highly branched poly(β-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold higher in vitro transfection efficiencies of different cell types in comparison to their linear LPAE counterparts as well as greatly out-performing the leading transfections reagents SuperFect and the "gold-standard" polyethyleneimine (PEI).

TL;DR: It is demonstrated that with highly branched poly(β-amino esters) (HPAEs), a type of recently developed gene delivery vector, the high gene transfection efficiency and low cytotoxicity can be achieved simultaneously at high molecular weight (MW).

TL;DR: Highly branched poly(β-amino esters) are developed via a facile and controllable "A2+B3/B2" strategy successfully and can achieve ultrahigh gene transfection efficiency, especially in keratinocytes.