L
Lars Akeroyd
Researcher at Utrecht University
Publications - 3
Citations - 1003
Lars Akeroyd is an academic researcher from Utrecht University. The author has contributed to research in topics: Cardiac function curve & Ventricular remodeling. The author has an hindex of 3, co-authored 3 publications receiving 847 citations.
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Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
Fatih Arslan,Ruenn Chai Lai,Ruenn Chai Lai,Mirjam B. Smeets,Lars Akeroyd,Andre Choo,Eissa N. E. Aguor,Leo Timmers,Harold V.M. van Rijen,Pieter A. Doevendans,Gerard Pasterkamp,Sai Kiang Lim,Dominique P.V. de Kleijn +12 more
TL;DR: This study shows that intact exosomes restore bioenergetics, reduce oxidative stress and activate pro-survival signaling, thereby enhancing cardiac function and geometry after myocardial I/R injury, and Hence, mesenchymal stem cell-derived exosome are a potential adjuvant to reperfusion therapy for my cardiac infarction.
Journal ArticleDOI
Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs
Fatih Arslan,Jaco H. Houtgraaf,Brian Keogh,Kushan Kazemi,Renate de Jong,William McCormack,Luke A. J. O'Neill,Peter McGuirk,Leo Timmers,Mirjam B. Smeets,Lars Akeroyd,Mary Reilly,Gerard Pasterkamp,Dominique P.V. de Kleijn +13 more
TL;DR: OPN-305 significantly reduces infarct size and preserves cardiac function in pigs after ischemia/reperfusion injury and is a promising adjunctive therapeutic for patients with acute myocardial infarction.
Journal ArticleDOI
Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction
Fatih Arslan,Mirjam B. Smeets,Brigitta Buttari,Elisabetta Profumo,Rachele Riganò,Lars Akeroyd,Emrah Kara,Leo Timmers,Joost P.G. Sluijter,Ben van Middelaar,Krista den Ouden,Gerard Pasterkamp,Sai Kiang Lim,Dominique P.V. de Kleijn +13 more
TL;DR: Haptoglobin deficiency severely deteriorates tissue repair and cardiac performance after experimental MI and plays a crucial role in both short- and long-term cardiac repair responses by reducing oxidative stress, maintaining microvascular integrity, myocardial architecture and proper scar formation.