L
Larsen Alf D
Researcher at University of Washington
Publications - 25
Citations - 3295
Larsen Alf D is an academic researcher from University of Washington. The author has contributed to research in topics: Complementary DNA & Peptide sequence. The author has an hindex of 15, co-authored 25 publications receiving 3273 citations.
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Journal ArticleDOI
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
PatentDOI
Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
Dirk M. Anderson,Michael A. Cantrell,Douglas P. Cerretti,Conlon Iii Paul J,David J. Cosman,Kenneth H. Grabstein,Larsen Alf D,Virginia L. Price +7 more
TL;DR: In this paper, homogeneous granulocyte-macrophage colony stimulating factor for use in activating macrophages and monocyte precursors is prepared by recombinant DNA techniques.
Journal ArticleDOI
Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.
TL;DR: Serologic analysis using a monoclonal antibody against purified recombinant interleukin 1 alpha proved conclusively that the potentiating activity in HBT 5637 serum-free supernatants is due to interlekina 1 alpha.
Journal ArticleDOI
Restricted production of interleukin 4 by activated human T cells
David B. Lewis,Kathryn S. Prickett,Larsen Alf D,Kenneth H. Grabstein,Michael J. Weaver,Christopher B. Wilson +5 more
TL;DR: Limitation of IL-4 production to a comparatively small population of normal human T cells could selectively regulate the effects of this lymphokine in T-cell-mediated immune responses; such selective regulation may be a fundamental mechanism for restricting the potentially pleiotropic effects of certain lymphokines to appropriate responder cells.
Journal ArticleDOI
Cloning of the Low-Affinity Murine Granulocyte-Macrophage Colony- Stimulating Factor Receptor and Reconstitution of a High-Affinity Receptor Complex
Linda S. Park,Unja Martin,Rick Sorensen,Sean Luhr,Philip J. Morrissey,David Cosman,Larsen Alf D +6 more
TL;DR: These studies show that clone 71 and AIC2B are capable of forming an alpha beta complex capable of binding murine GM-CSF with high affinity, while Aic2A appears not to be a component of the murineGM- CSF receptor.