Laura Ceballos-Laita

TL;DR: Quercetin, with well-known pharmacokinetic and ADMET properties, can be considered as a good candidate for further optimization and development, or repositioned for COVID-19 therapeutic treatment.

TL;DR: Comparisons of the proteomes of the three plant fluids indicates that although functional categories are somewhat similar, proteins involved are likely to be fluid-specific, except for a small group of proteins present in the three fluids, which may have a universal role, especially in cell wall maintenance and defense.

TL;DR: In this article, the authors used rutin, a natural flavonoid that is the most common glycosylated conjugate of quercetin, as a model combining experimental (spectroscopy and calorimetry) and simulation techniques (docking and molecular dynamics simulations).

TL;DR: Polypeptide GalNAc-T3 catalyzes the specific glycosylation of threonine-178 of fibroblast growth factor 23, and structural insights reveal a unique lectin-based mechanism of substrate recognition.

TL;DR: Crystal structure of FUT8 complexed with GDP and a biantennary complex N -glycan provides insight into both substrate recognition and catalysis, and serves as a framework for inhibitor design, and helps to assess its potential as a therapeutic target.