Laura M. Castellano

TL;DR: It is established that disease-associated aggregates and amyloid are tractable targets and that enhanced disaggregases can restore proteostasis and mitigate neurodegeneration.

TL;DR: The results suggest that the partial agonists varenicline and sazetidine-A may have diverse therapeutic benefits in affective disorders.

TL;DR: Varenicline has been shown to be an efficacious smoking cessation aid, with a proposed mechanism of action that includes modulation of dopamine release in reward areas of the brain that suggests receptor upregulation as a mechanism for its efficacy as a smoking cessation therapy.

TL;DR: NBD conformations at the seam interface reveal how ATP hydrolysis-driven substrate disengagement and re-binding are precisely tuned to drive a directional, stepwise translocation cycle.

TL;DR: Combined anti-amyloid and antiviral activities make CLR01 a promising topical microbicide for blocking infection by HIV and other sexually transmitted viruses.