L
Laurence Daheron
Researcher at Harvard University
Publications - 37
Citations - 4916
Laurence Daheron is an academic researcher from Harvard University. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 25, co-authored 34 publications receiving 4611 citations. Previous affiliations of Laurence Daheron include Boston Children's Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models
Qiurong Ding,Youn-Kyoung Lee,Esperance A. Schaefer,Derek T. Peters,Adrian Veres,Kevin J. Kim,Nicolas Kuperwasser,Nicolas Kuperwasser,Daniel L. Motola,Torsten B. Meissner,William T. Hendriks,Marta Trevisan,Rajat M. Gupta,Rajat M. Gupta,Annie Moisan,Eric Banks,Max Friesen,Robert T. Schinzel,Fang Xia,Alexander Tang,Yulei Xia,Emmanuel Figueroa,Amy Wann,Tim Ahfeldt,Laurence Daheron,Feng Zhang,Feng Zhang,Lee L. Rubin,Lee F. Peng,Raymond T. Chung,Kiran Musunuru,Chad A. Cowan +31 more
TL;DR: Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a genome than previous types of nucleases as discussed by the authors.
Journal ArticleDOI
LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells
Laurence Daheron,Sarah L. Opitz,Holm Zaehres,William M. Lensch,Peter W. Andrews,Joseph Itskovitz-Eldor,George Q. Daley +6 more
TL;DR: It is shown that the LIFRβ and the signaling subunit gp130 are expressed in hESCs and that human LIF can induce STAT3 phosphorylation and nuclear translocation in h ESCs, Nevertheless, despite the functional activation of the Lif‐STAT3 signaling pathway, human Lif is unable to maintain the pluripotent state of hEScs.
Journal ArticleDOI
A comparison of non-integrating reprogramming methods.
Thorsten M. Schlaeger,Laurence Daheron,Thomas Brickler,Samuel W. Entwisle,Karrie Chan,Amelia Cianci,Alex Devine,Andrew Ettenger,Kelly Fitzgerald,Michelle Godfrey,Dipti Gupta,Jade McPherson,Prerana Malwadkar,Manav Gupta,Blair Bell,Akiko Doi,Namyoung Jung,Xin Li,Maureen M. Lynes,Emily Brookes,Anne Cherry,Didem Demirbas,Alexander M. Tsankov,Leonard I. Zon,Lee L. Rubin,Andrew P. Feinberg,Alexander Meissner,Chad A. Cowan,George Q. Daley +28 more
TL;DR: Comparing Sendai-viral (SeV), episomal (Epi) and mRNA transfection mRNA methods for generating integration-free hiPSCs provides a valuable resource to inform the use of specific reprogramming methods for different laboratories and different applications, including clinical translation.
Journal ArticleDOI
A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness
Caroline J. Woo,Peter V. Kharchenko,Peter V. Kharchenko,Laurence Daheron,Peter J. Park,Peter J. Park,Robert E. Kingston +6 more
TL;DR: It is concluded that D11.12 is a Polycomb-dependent regulatory region with similarities to Drosophila PREs, indicating conservation in the mechanisms that target PcG function in mammals and flies.
Journal ArticleDOI
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
Patrick Au,Patrick Au,Laurence Daheron,Dan G. Duda,Kenneth S. Cohen,James Alex Tyrrell,Ryan M. Lanning,Ryan M. Lanning,Dai Fukumura,David T. Scadden,Rakesh K. Jain +10 more
TL;DR: It is found that umbilical cord blood EPCs form normal-functioning blood vessels that last for more than 4 months, and these vessels exhibit normal blood flow, perm-selectivity to macromolecules, and induction of leukocyte-endothelial interactions in response to cytokine activation similar to normal vessels.