L
Laurence Loewe
Researcher at University of Wisconsin-Madison
Publications - 41
Citations - 1553
Laurence Loewe is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Population & Muller's ratchet. The author has an hindex of 19, co-authored 41 publications receiving 1409 citations. Previous affiliations of Laurence Loewe include Wisconsin Institutes for Discovery & Technische Universität München.
Papers
More filters
Journal ArticleDOI
The population genetics of mutations: good, bad and indifferent
Laurence Loewe,William G. Hill +1 more
TL;DR: This introduction to more detailed papers that follow, which aim to provide an oversight of the field of population genetics, reviews current knowledge on mutation rates and their harmful and beneficial effects on fitness and considers theories that predict the fate of individual mutations or the consequences of mutation accumulation for quantitative traits.
Journal ArticleDOI
Estimating Selection on Nonsynonymous Mutations
TL;DR: Two methods for characterizing the fitness effects of deleterious, nonsynonymous mutations are developed, using polymorphism data from two related species, and a simple approximate method for estimating the harmonic mean selection coefficient from diversity data on a single species is described.
Journal ArticleDOI
Recombination modulates how selection affects linked sites in Drosophila.
Suzanne E. McGaugh,Caiti Smukowski Heil,Brenda Manzano-Winkler,Laurence Loewe,Steve Goldstein,Tiffany Himmel,Mohamed A. F. Noor +6 more
TL;DR: Recombination rate in Drosophila species shapes the impact of selection in the genome and is positively correlated with nucleotide diversity.
Journal ArticleDOI
Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly
Wesley C. Warren,Raquel García-Pérez,Sen Xu,Kathrin P. Lampert,Domitille Chalopin,Matthias Stöck,Laurence Loewe,Yuan Lu,Lukas F. K. Kuderna,Patrick Minx,Michael J. Montague,Chad Tomlinson,LaDeana W. Hillier,Daniel N. Murphy,John Wang,Zhongwei Wang,Zhongwei Wang,Constantino Macías Garcia,Gregg C.W. Thomas,Jean Nicolas Volff,Fabiana H.G. Farias,Bronwen Aken,Ronald B. Walter,Kim D. Pruitt,Tomas Marques-Bonet,Tomas Marques-Bonet,Matthew W. Hahn,Susanne Kneitz,Michael Lynch,Manfred Schartl,Manfred Schartl +30 more
TL;DR: The data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.
Journal ArticleDOI
Inferring the distribution of mutational effects on fitness in Drosophila.
TL;DR: Several important parameters, such as the fraction of effectively neutral non-synonymous mutations and the harmonic mean of non-neutral selection coefficients, are robust to the form of the DDME.