L
Laurens M. De Coen
Researcher at Ghent University
Publications - 18
Citations - 270
Laurens M. De Coen is an academic researcher from Ghent University. The author has contributed to research in topics: Bicyclic molecule & Ring (chemistry). The author has an hindex of 7, co-authored 18 publications receiving 198 citations.
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Journal ArticleDOI
Synthetic Entries to and Biological Activity of Pyrrolopyrimidines
TL;DR: This review summarizes recent literature on the synthesis and pharmaceutical properties of pyrrolopyrimidines and contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold.
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Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives.
TL;DR: These structures can be considered as good starting points for the development of new powerful antimycobacterial agents, according to the acid dissociation constants of these compounds.
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Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes.
Bart Roman,Laurens M. De Coen,Séverine Thérèse F.C. Mortier,Tine De Ryck,Barbara Vanhoecke,Alan R. Katritzky,Alan R. Katritzky,Marc Bracke,Christian V. Stevens +8 more
TL;DR: A number of structurally related (E)- and (Z)-stilbenes exhibited an extraordinary high in vitro potency in the chick heart invasion assay, being active up to 10nmolL(-1), a concentration level a 100-fold lower than the lowest effective doses that have been reported for natural analogues.
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Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity
TL;DR: In this paper, a series of 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C.
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Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
Tine De Ryck,Eline Vanlancker,Charlotte Grootaert,Bart Roman,Laurens M. De Coen,Isabel Vandenberghe,Christian V. Stevens,Marc Bracke,Tom Van de Wiele,Barbara Vanhoecke +9 more
TL;DR: The results are important for the development of new strategies for the management of (infected) wounds and ulcerations and hypothesized that quorum sensing molecules might play a role in the inter-kingdom signalling during wound healing.