L
Laurent Baricault
Researcher at Paul Sabatier University
Publications - 8
Citations - 1605
Laurent Baricault is an academic researcher from Paul Sabatier University. The author has contributed to research in topics: Mitochondrial apoptosis-induced channel & Mitochondrion. The author has an hindex of 8, co-authored 8 publications receiving 1496 citations. Previous affiliations of Laurent Baricault include University of Toulouse.
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Journal ArticleDOI
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
Aurélien Olichon,Laurent Baricault,Nicole Gas,Emmanuelle Guillou,Annie Valette,Pascale Belenguer,Guy Lenaers +6 more
TL;DR: It is suggested that OPA1 is a major organizer of the mitochondrial inner membrane from which the maintenance of the cristae integrity depends and that abnormal apoptosis is a possible pathophysiological process leading to the retinal ganglion cells degeneration in ADOA patients.
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OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis
Aurélien Olichon,Aurélien Olichon,Ghizlane Elachouri,Laurent Baricault,Cécile Delettre,Pascale Belenguer,Guy Lenaers,Guy Lenaers +7 more
TL;DR: It is shown that Ex4 that is conserved throughout evolution confers functions to OPA1 involved in the maintenance of the ΔΨm and in the fusion of the mitochondrial network.
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OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals.
Laurent Baricault,Bruno Ségui,Laurie Guégand,Aurélien Olichon,Annie Valette,Florence Larminat,Guy Lenaers +6 more
TL;DR: The results suggest that the ATP-dependent OPA1 processing plays a central role in correlating the energetic metabolism to mitochondrial dynamic and might be involved in the pathophysiology of diseases associated to excess of iron or depletion of zinc and ATP.
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OPA1 functions in mitochondria and dysfunctions in optic nerve
Guy Lenaers,Pascal Reynier,Ghizlane Elachouri,Chadi Soukkarieh,Aurélien Olichon,Pascale Belenguer,Laurent Baricault,Bernard Ducommun,Christian P. Hamel,Cécile Delettre +9 more
TL;DR: The fundamental knowledge on OPA1 functions and regulations are reviewed, highlighting their involvements in mitochondrial respiration, membrane dynamic and apoptosis, and the remarkable RGC mitochondrial network physiology is described.
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Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells.
TL;DR: It is demonstrated here that low doses of PTX that are unable to activate the spindle assembly checkpoint, upregulate p21 by a p53-dependent pathway and induce its translocation to the cytoplasm.