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Wei Shi
Researcher at QIMR Berghofer Medical Research Institute
Publications - 39
Citations - 2497
Wei Shi is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Cancer & DNA repair. The author has an hindex of 17, co-authored 33 publications receiving 1830 citations. Previous affiliations of Wei Shi include Vaccine Research Center & University of Michigan.
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Journal ArticleDOI
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Jesper Pallesen,Nianshuang Wang,Kizzmekia S. Corbett,Daniel Wrapp,Robert N. Kirchdoerfer,Hannah L. Turner,Christopher A. Cottrell,Michelle M. Becker,Lingshu Wang,Wei Shi,Wing-Pui Kong,Erica L. Andres,Arminja N. Kettenbach,Mark R. Denison,Mark R. Denison,James D. Chappell,Barney S. Graham,Andrew B. Ward,Jason S. McLellan +18 more
TL;DR: An engineering strategy for stabilization of soluble S proteins in the prefusion conformation is described, which results in greatly increased expression, conformational homogeneity, and elicitation of potent antibody responses, and an engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV.
Journal ArticleDOI
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
Davide Corti,John Misasi,Sabue Mulangu,Daphne A. Stanley,Masaru Kanekiyo,Suzanne E. Wollen,Aurélie Ploquin,Nicole A. Doria-Rose,Ryan P. Staupe,Michael Bailey,Wei Shi,Misook Choe,Hadar Marcus,Emily A. Thompson,Alberto Cagigi,Chiara Silacci,Blanca Fernandez-Rodriguez,Laurent Perez,Federica Sallusto,Fabrizia Vanzetta,Gloria Agatic,Elisabetta Cameroni,Neville K. Kisalu,Ingelise J. Gordon,Julie E. Ledgerwood,John R. Mascola,Barney S. Graham,Jean-jacques Muyembe-Tamfun,John C. Trefry,Antonio Lanzavecchia,Antonio Lanzavecchia,Nancy J. Sullivan +31 more
TL;DR: It is ascertained that a human survivor of the 1995 Kikwit Ebola virus disease outbreak maintained circulating antibodies against the Ebola virus surface glycoprotein for more than a decade after infection, suggesting that a simplified therapeutic strategy for human Ebola infection may be possible.
Journal ArticleDOI
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
Ming Tian,Ming Tian,Cheng Cheng,Xuejun Chen,Hongying Duan,Hwei-Ling Cheng,Hwei-Ling Cheng,Mai Dao,Mai Dao,Zizhang Sheng,Michael T. Kimble,Michael T. Kimble,Lingshu Wang,Sherry Lin,Sherry Lin,Stephen D. Schmidt,Zhou Du,Zhou Du,M. Gordon Joyce,Yiwei Chen,Yiwei Chen,Brandon J. DeKosky,Yimin Chen,Yimin Chen,Erica Normandin,Elizabeth Cantor,Elizabeth Cantor,Rita E. Chen,Nicole A. Doria-Rose,Yi Zhang,Wei Shi,Wing-Pui Kong,Misook Choe,Amy R. Henry,Farida Laboune,Ivelin S. Georgiev,Pei-Yi Huang,Pei-Yi Huang,Suvi Jain,Suvi Jain,Andrew T. McGuire,Eric Georgeson,Sergey Menis,Daniel C. Douek,William R. Schief,William R. Schief,William R. Schief,Leonidas Stamatatos,Peter D. Kwong,Lawrence Shapiro,Lawrence Shapiro,Barton F. Haynes,John R. Mascola,Frederick W. Alt,Frederick W. Alt +54 more
TL;DR: A mouse vaccination model is described that allows a germline human IGHV1-2(∗)02 segment to undergo normal V(D)J recombination and leads to the generation of peripheral B cells that express a highly diverse repertoire of VRC01-related receptors.
Journal ArticleDOI
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Lang Wu,Wei Shi,Jirong Long,Xingyi Guo,Kyriaki Michailidou,Kyriaki Michailidou,Jonathan Beesley,Manjeet K. Bolla,Xiao-Ou Shu,Yingchang Lu,Qiuyin Cai,Fares Al-Ejeh,E Rozali,Qin Wang,Joe Dennis,Bingshan Li,Chenjie Zeng,Helian Feng,Alexander Gusev,Richard Barfield,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Kristan J. Aronson,Paul L. Auer,Paul L. Auer,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Javier Benitez,Marina Bermisheva,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Louise A. Brinton,Per Broberg,Sara Y. Brucker,Barbara Burwinkel,Barbara Burwinkel,Trinidad Caldés,Federico Canzian,Brian D. Carter,J. Esteban Castelao,Jenny Chang-Claude,Jenny Chang-Claude,Xiaoqing Chen,Tongguang Cheng,Hans Christiansen,Christine L. Clarke,Margriet Collée,Sten Cornelissen,Fergus J. Couch,David Cox,David Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Miriam Dwek,Diana Eccles,Ursula Eilber,A. Heather Eliassen,Christoph Engel,Mikael Eriksson,Laura Fachal,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Marike Gabrielson,Manuela Gago-Dominguez,Susan M. Gapstur,Montserrat Garcia-Closas,Mia M. Gaudet,Maya Ghoussaini,Graham G. Giles,Graham G. Giles,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Pascal Guénel,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Per Hall,Emily Hallberg,Ute Hamann,Patricia Harrington,Alexander Hein,Belynda Hicks,Peter Hillemanns,Antoinette Hollestelle,Robert N. Hoover,John L. Hopper,Guanmengqian Huang,Keith Humphreys,David J. Hunter,David J. Hunter,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Audrey Y. Jung,Rudolf Kaaks,Michael J. Kerin,Elza Khusnutdinova,Elza Khusnutdinova,Veli-Matti Kosma,Vessela N. Kristensen,Diether Lambrechts,Loic Le Marchand,Jingmei Li,Sara Lindström,Sara Lindström,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jan Lubinski,Craig Luccarini,Michael P. Lux,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Ivana Maleva Kostovska,Ivana Maleva Kostovska,Arto Mannermaa,JoAnn E. Manson,Sara Margolin,Dimitrios Mavroudis,Hanne Meijers-Heijboer,Alfons Meindl,Usha Menon,J.-P. Meyer,Anna Marie Mulligan,Anna Marie Mulligan,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Børge G. Nordestgaard,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Paolo Peterlongo,Julian Peto,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gad Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Atocha Romero,Jane Romm,Anja Rudolph,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Marjanka K. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Mitul Shah,Martha J. Shrubsole,Ann Smeets,Melissa C. Southey,John J. Spinelli,Jennifer Stone,Jennifer Stone,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Mary Beth Terry,Daniel C. Tessier,Abigail Thomas,Kathrin Thöne,Rob A. E. M. Tollenaar,Diana Torres,Diana Torres,Thérèse Truong,Michael Untch,Celine M. Vachon,David Van Den Berg,Daniel Vincent,Quinten Waisfisz,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Lucy Xia,Xiaohong R. Yang,Argyrios Ziogas,Elad Ziv,Alison M. Dunning,Paul D.P. Pharoah,Jacques Simard,Roger L. Milne,Roger L. Milne,Stacey L. Edwards,Peter Kraft,Douglas F. Easton,Georgia Chenevix-Trench,Wei Zheng +234 more
TL;DR: A transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci at loci not yet reported for breast cancer.
Journal ArticleDOI
Novel Common Genetic Susceptibility Loci for Colorectal Cancer
Stephanie L. Schmit,Christopher K. Edlund,Fredrick R. Schumacher,Jian Gong,Tabitha A. Harrison,Jeroen R. Huyghe,Chenxu Qu,Marilena Melas,David Van Den Berg,Hansong Wang,Stephanie Tring,Sarah J. Plummer,Demetrius Albanes,M. Henar Alonso,Christopher I. Amos,Kristen Anton,Aaron K. Aragaki,Volker Arndt,Elizabeth L. Barry,Sonja I. Berndt,Stéphane Bézieau,Stephanie A. Bien,Amanda Bloomer,Juergen Boehm,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Hermann Brenner,Stefanie Brezina,Daniel D. Buchanan,Daniel D. Buchanan,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Chris S. Carlson,Jose E. Castelao,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Iona Cheng,Ya Wen Cheng,Lee Soo Chin,James M. Church,Timothy R. Church,Gerhard A. Coetzee,Michelle Cotterchio,Marcia Cruz Correa,Keith R. Curtis,David Duggan,Douglas F. Easton,Dallas R. English,Edith J. M. Feskens,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,Barbara K. Fortini,Lars G. Fritsche,Lars G. Fritsche,Charles S. Fuchs,Charles S. Fuchs,Manuela Gago-Dominguez,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Edward Giovannucci,Stephanie M. Gogarten,Clicerio Gonzalez-Villalpando,Elena M. Gonzalez-Villalpando,William M. Grady,Joel K. Greenson,Andrea Gsur,Marc J. Gunter,Christopher A. Haiman,Jochen Hampe,Sophia Harlid,John F. Harju,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,Shu Chen Huang,José María Huerta,Thomas J. Hudson,David J. Hunter,Gregory Idos,Motoki Iwasaki,Rebecca D. Jackson,Eric J. Jacobs,Sun Ha Jee,Mark A. Jenkins,Weihua Jia,Shuo Jiao,Amit Joshi,Laurence N. Kolonel,Suminori Kono,Charles Kooperberg,Vittorio Krogh,Tilman Kuehn,Sébastien Küry,Andrea Z. LaCroix,Cecelia A. Laurie,Flavio Lejbkowicz,Flavio Lejbkowicz,Mathieu Lemire,Heinz-Josef Lenz,David N. Levine,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Noralane M. Lindor,Yun Ru Liu,Fotios Loupakis,Yingchang Lu,Frank Luh,Jing Ma,Christoph Mancao,Frank J. Manion,Sanford D. Markowitz,Vicente Martín,Koichi Matsuda,Koichi Matsuda,Keitaro Matsuo,Kevin McDonnell,Caroline McNeil,Roger L. Milne,Roger L. Milne,Antonio J. Molina,Bhramar Mukherjee,Neil Murphy,Polly A. Newcomb,Kenneth Offit,Hanane Omichessan,Hanane Omichessan,Domenico Palli,Jesus P. Paredes Cotoré,Julyann Pérez-Mayoral,Paul D.P. Pharoah,John D. Potter,Conghui Qu,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Bridget M. Riggs,Clemens Schafmayer,Robert E. Schoen,Thomas A. Sellers,Daniela Seminara,Gianluca Severi,Wei Shi,David Shibata,Xiao-Ou Shu,Erin M. Siegel,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Zsofia K. Stadler,Mariana C. Stern,Sebastian Stintzing,Darin Taverna,Stephen N. Thibodeau,Duncan C. Thomas,Antonia Trichopoulou,Shoichiro Tsugane,Cornelia M. Ulrich,Fränzel J.B. van Duijnhoven,Bethany van Guelpan,Joseph Vijai,Jarmo Virtamo,Stephanie J. Weinstein,Emily White,Aung Ko Win,Alicja Wolk,Michael O. Woods,Anna H. Wu,Kana Wu,Yong-Bing Xiang,Yun Yen,Brent W. Zanke,Brent W. Zanke,Yi Xin Zeng,Ben Zhang,Niha Zubair,Sun-Seog Kweon,Jane C. Figueiredo,Jane C. Figueiredo,Wei Zheng,Loic Le Marchand,Annika Lindblom,Victor Moreno,Ulrike Peters,Graham Casey,Li Hsu,David V. Conti,Stephen B. Gruber +198 more
TL;DR: This article identified 42 loci (P < 5x10−8) associated with risk of colorectal cancer (CRC) and expanded consortium efforts facilitating the discovery of these loci.