L
Laurent Servais
Researcher at University of Oxford
Publications - 223
Citations - 7546
Laurent Servais is an academic researcher from University of Oxford. The author has contributed to research in topics: Spinal muscular atrophy & Medicine. The author has an hindex of 39, co-authored 183 publications receiving 5213 citations. Previous affiliations of Laurent Servais include Pierre-and-Marie-Curie University & Radboud University Nijmegen.
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Journal ArticleDOI
Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
Richard S. Finkel,Eugenio Mercuri,Basil T. Darras,Anne M. Connolly,Nancy L. Kuntz,Janbernd Kirschner,Claudia A. Chiriboga,Kayoko Saito,Laurent Servais,Eduardo F. Tizzano,Haluk Topaloglu,Mar Tulinius,Jacqueline Montes,Allan M. Glanzman,Kathie M. Bishop,Z. John Zhong,Sarah Gheuens,C. Frank Bennett,Eugene Schneider,Wildon Farwell,Darryl C. De Vivo,Walter G. Bradley,M. K. Schroth,J. B. Bodensteriner,C. S. Davis,R. Shell,J. Hen,E. D. Austin,S. Aziz-Zaman,J. Cappell,Andrei Constantinescu,Rosangel Cruz,Jahannaz Dastgir,Sally Dunaway,K. Engelstad,M. Gormley,N. Holuba La Marca,Alexander G. Khandji,S. Kramer,Jonathan Marra,C. Ortiz-Miller,M. Popolizio,Rachel Salazar,L. Sanabria,L. Weimer,Pallavi Anand,R. Gadeken,Paul T. Golumbek,Catherine Siener,Craig M. Zaidman,Fouad Al-Ghamdi,C. Berde,Partha S. Ghosh,Robert J. Graham,Tim Harrington,A. Koka,R. Laine,W. Liew,Elizabeth Mirek,G. Ordonez,Amy Pasternak,Janet Quigley,Navil F. Sethna,M. Souris,Heather Szelag,L. Wand,John W. Day,Genevieve D'Souza,T. T. Duong,Richard Gee,J. Kitsuwa-Lowe,D. McFall,S. Patnaik,S. Paulose,Jennifer Perez,Christopher Proud,B. Purse,R. J. Ramamurthi,Sarada Sakamuri,Jacinda B. Sampson,B. Sanjanwala,A. C. Tesi Rocha,K. Watson,L. Welsh,L.D.M. Peña,Laura E. Case,J. Coates,Stephanie DeArmey,M. M. Homi,C. Milleson,N. Nelson,Alexandra C. Ross,Edward C. Smith,B. Taicher,J. Wootton,Erika Finanger,D. Benjamin,A. Frank,Catherine E. Roberts,Barry S. Russman,K. Zilke,D. Berry,Matthew Civitello,D. Cook,J. D. Endsley,C. Johnson,M. Kasper,W. Leon,A. Lim,K. O'Reardon,L. Y. Sigurdardottir,J. Turner,F. Weber-Guzman,M. Zinn,Susan T. Iannaccone,Diana Castro,M. Cowie,Alan C Farrow-Gillespie,A. Herbert,M. Kauk,D. McElroy,N. Miller,Leslie Nelson,Luke Smith,T. Spain,S. Trest,Nicholas E. Johnson,Russell J. Butterfield,D. DiBella,K. Mayne,T. M. Newcomb,N. Rausch,C. Blomgren,H. W. Choi,Leon G. Epstein,S. Goldman,Kristin J. Krosschell,Jena M. Krueger,Jonathan E. Kurz,Vamshi K. Rao,Julie A. Parsons,V. Allen,Alan Bielsky,K. Booker,A. Camuto,Terri Carry,Peter G. Fuhr,Melissa Gibbons,J. Janas,H. Johnson,C. Kelly,L. S. Lord-Halvorson,S. Nicolarsen,S. Shea,V. Tran,G. VanderVeen,M. Yang,C. Zimmerman,Perry B. Shieh,N. Parziale,L. Rao,J. W. Said,F. Shu,C. Skura,L. Staudt,Gihan Tennekoon,L. Adang,John F. Brandsema,M. Chadehumbe,Jean Flickinger,Elizabeth Kichula,D. Stanford,M. Toms,J. Zigmont,Maryam Oskoui,S. Arpin,P. Dinunzio,P. M. Ingelmo,C. Poulin,G. Rivera,C. Sabapathy,M. Srour,S. Turgeon-Desilet,D. Zielinski,Kathryn Selby,C. King,J. Lee,A. Michoulas,E. Roland,Jiri Vajsar,V. Chau,James J. Dowling,R. Haldenby,M. Miki,S. So,S. I. Pascual Pascual,A. Martinez Bermejo,S. Epinosa Garcia,S. Garcia Guixot,M. M. Martinez Moreno,M. del Pilar Tirado Requero,M. del Mar Garcia Romero,C. Aguilar,F. Munell Casadesus,M. B. Gomez Garcia de la Banda,M. Gallardo,G. Gili,M. Alavarez Molinero,M. de Los Angeles Tormos Munoz,N. J. Palacios,B. Planas Pascual,M. del Mar Melendez Plumed,A. F. Rucian,E. Toro Tamargo,M. Gratacos Vinola,S. Borell,Matthias Eckenweiler,Marcus Krüger,Astrid Pechmann,B. Rippberger,S. Stein,Sibylle Vogt,S. Wider,Ulrike Schara,B. Andres,A. Della Marina,A. Ganfuss,P. Jachertz,Heike Koelbel,K. Rupprich,E. S. Schroers,N. Sponemann,Claudio Bruno,Chiara Fiorillo,Alberto Garaventa,Paola Lanteri,Valentina Lanzillotta,C. Manzitti,M. Pedermonte,Paola Tacchetti,Federica Trucco,A. Zuffi,R. De Sanctis,Lavinia Fanelli,Marco Luigetti,Concetta Palermo,Marika Pane,Marco Piastra,Serena Sivo,E. Gargaun,Teresa Gidaro,S. Gilabert,P. L. Léger,A. G. Le Moing,C. Lilien,Michèle Mayer,Q. Ollievier,J. Rambaud,Jessica Taytard,R. Vialle,T. Voit,Francesco Muntoni,L. D'Argenzio,PH Lister,Adnan Y. Manzur,J. Pisco Domingos,Danielle Ramsey,Valeria Ricotti,L. Schottlaender,Mariacristina Scoto,S. M. Scuplak,V. Selby,Volker Straub,S. Baily,Marta Bertoli,A. Mayhew,Robert Muni Lofra,Adrian Murphy,Claire L Wood,Niklas Darin,J. Eldblom,E. Kimber,A. K. Kroksmark,A. Lindstedt,E. Michael,Kalliopi Sofou,Nicolas Deconinck,A. Christiaens,Sandra Coppens,K. DeCock,E. De Vos voor,F. Dorban,G. Gilbert,S. Rooze,V. Tahon,R. Van Coster,R. Van Der Looven,Arnaud Vanlander,D. Vens,Helene Verhelst,B. Wenderickx,S. Wittevrongel,Michelle A. Farrar,N. Berthon-Jones,Michael Doumit,Karen Herbert,Tejaswi Kandula,Margot Morrison,J. O'Brien,S. Richardson,H. A. Ferreira Sampaio,H. L. Teoh,Monique M. Ryan,K. Carroll,K. L. De Valle,D. Villano,Ian R. Woodcock,E. M. Yiu,Didem Ardicli,C. Gunbey,V. G. Haliloglu,Ayşe Karaduman,Bahadır Konuşkan,F. G. Yildiz Sarikaya,E. Serdaroglu,M. Tanyildiz,C. M. Temucin,Mirac Yildirim,Öznur Yilmaz,R. Arakawa,Y. Chiba,K. Eto,K. Hirasawa,T. Ikai,S. Ito,Y. Ito,Y. Kaburagi,H. Kaneko,S. Matsumaru,N. Matsushima,K. Mizuochi,S. Nagata,H. Nakatsukasa,A. Nishikawa,Y. Otani,T. Sato,M. Shichiji,K. Sugimoto,A. Takeshita,T. Yanagishita,A. Yamauchi,Y. Takeshima,T. Fujino,N. Fukuda,T. Lee,K. Oriyama,T. Shibano,H. Shimomura,T. Tachikawa,Y. Tanaka,N. Taniguchi,Jong-Hee Chae,S. A. Choi,S. M. Chun,H. Jo,H. Kim,S. Y. Kim,J. S. Lee,B. C. Lim,Hyung Ik Shin,W. S. Son,Sophelia H. S. Chan,A. C. Chung,C. S. Yan,C. Stella,C. K.W. Joseph,C. S. Ng,H. C.C. Alvin,I. J.K. Janice,L. W.M. Wendy,M. N. Chui-San,N. Y. Ki,T. N. Shun,W. Y. Connie,W. C. Virginia,Y. Yvonne,Y. J. Jong,Tai-Heng Chen,P. C. Chou,Y. H. Chou,H. W. Chung,J. H. Hsu,Y. H. Ju,W. C. Liang,H. H. Shih,H. Y. Wang,Y. C. Wu,Y. S. Zeng +397 more
TL;DR: Those who received nusinersen were more likely to be alive and have improvements in motor function than those in the control group and infants with a shorter disease duration at screening wereMore likely than those with a longer disease duration to benefit from nusineren.
Journal ArticleDOI
Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study.
Thomas Voit,Haluk Topaloglu,Volker Straub,Francesco Muntoni,Nicolas Deconinck,Giles G Campion,Sjef J. de Kimpe,Michelle Eagle,Michela Guglieri,Steve S Hood,Lia Liefaard,Afrodite Lourbakos,Allison A Morgan,Joanna Nakielny,Naashika Quarcoo,Valeria Ricotti,Katie Rolfe,Laurent Servais,C. Wardell,Rosamund Wilson,Padraig Wright,Padraig Wright,John E. Kraus +22 more
TL;DR: Continuous drisapersen resulted in some benefit in 6MWD versus placebo at week 25 in patients in the intention-to-treat population for whom data were available, andAmbulation improvements in this young population with early-stage Duchenne muscular dystrophy are encouraging but need to be confirmed in larger studies.
Journal ArticleDOI
Anti-HMGCR autoantibodies in European patients with autoimmune necrotizing myopathies: inconstant exposure to statin.
Yves Allenbach,Laurent Drouot,Aude Rigolet,Jean Luc Charuel,Fabienne Jouen,Norma B. Romero,Thierry Maisonobe,Odile Dubourg,Anthony Behin,Pascal Laforêt,T. Stojkovic,Bruno Eymard,Nathalie Costedoat-Chalumeau,Emmanuelle Campana-Salort,Anne Tournadre,Lucile Musset,Brigitte Bader-Meunier,Isabelle Koné-Paut,Jean Sibilia,Laurent Servais,Olivier Fain,Claire Larroche,Elisabeth Diot,Benjamin Terrier,Raphael De Paz,Antoine Dossier,Dominique Menard,Chafika Morati,Marielle Roux,Xavier Ferrer,Jérémie Martinet,Sophie Besnard,Rémi Bellance,Patrice Cacoub,Laurent Arnaud,Bernard Grosbois,Serge Herson,Olivier Boyer,Olivier Benveniste +38 more
TL;DR: This study confirms the observation and description of anti-HMGCR aAb associated with NAM, and titers correlated with CK levels and muscle strength, suggesting their pathogenic role.
Journal ArticleDOI
Sexual health care in persons with intellectual disabilities.
TL;DR: From this review, it appears that hygiene management, global gynecological care, and prevention of unplanned pregnancy, sexually transmitted diseases, and abuse have been frequently identified as areas in which the presence of intellectual disability dictates specific support needs.
Journal ArticleDOI
Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy.
D. Frank,F.J. Schnell,Cody Akana,Saleh El-Husayni,Cody A. Desjardins,Jennifer E. Morgan,Jay S. Charleston,Valentina Sardone,Joana Domingos,George Dickson,Volker Straub,Michela Guglieri,Eugenio Mercuri,Laurent Servais,Francesco Muntoni +14 more
TL;DR: This study provides Class I evidence that golodirsen is safe and Class IV evidence that it induces exon skipping and novel dystrophin as confirmed by 3 different assays.