L
Lawrence Lin
Researcher at University of California, San Francisco
Publications - 13
Citations - 992
Lawrence Lin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Phenylalanine & Metformin. The author has an hindex of 10, co-authored 13 publications receiving 756 citations. Previous affiliations of Lawrence Lin include Carnegie Mellon University.
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Journal ArticleDOI
SLC transporters as therapeutic targets: emerging opportunities
TL;DR: Current and investigational drugs that modulate SLC transporters, as well as promising drug targets, are highlighted.
Journal ArticleDOI
A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains
Michael Gamalinda,Uli Ohmayer,Jelena Jakovljevic,Beril Kumcuoglu,Joshua Woolford,Bertrade C. Mbom,Lawrence Lin,John L. Woolford +7 more
TL;DR: This model provides an initial paradigm for the sequential assembly of eukaryotic 60S subunits and reveals striking differences and similarities between assembly of bacterial and eukARYotic large ribosomal subunits, providing insights into how these RNA-protein particles evolved.
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A genome-wide association study of bronchodilator response in Latinos implicates rare variants
Katherine A. Drake,Dara G. Torgerson,Christopher R. Gignoux,Joshua Galanter,Lindsey A. Roth,Scott Huntsman,Celeste Eng,Sam S. Oh,Sook Wah Yee,Lawrence Lin,Carlos Bustamante,Andrés Moreno-Estrada,Karla Sandoval,Adam Davis,Luisa N. Borrell,Harold J. Farber,Rajesh Kumar,Pedro C. Avila,Emerita Brigino-Buenaventura,Rocio Chapela,Jean G. Ford,Michael A. LeNoir,Fred Lurmann,Kelley Meade,Denise Serebrisky,Shannon Thyne,William Rodriguez-Cintron,Saunak Sen,Jose R. Rodriguez-Santana,Ryan D. Hernandez,Kathleen M. Giacomini,Esteban G. Burchard +31 more
TL;DR: The results suggest that rare variation contributes to individual differences in response to albuterol in Latinos, notably in SLC genes that include membrane transport proteins involved in the transport of endogenous metabolites and xenobiotics.
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LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates
Arik A. Zur,Huan-Chieh Chien,Evan Augustyn,Andrew Flint,Nathan Heeren,Karissa Finke,Christopher Hernandez,Logan Hansen,Sydney Miller,Lawrence Lin,Kathleen M. Giacomini,Claire Colas,Avner Schlessinger,Allen A. Thomas +13 more
TL;DR: The results lend support to a recent account that amino acid esters are LAT1 substrates, and that hydrogen bonding may be as important as charge for interaction with the transporter binding site.
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Genomic Characterization of Metformin Hepatic Response
Marcelo R. Luizon,Walter L. Eckalbar,Yao Wang,Yao Wang,Stacy L. Jones,Robin P. Smith,Megan Laurance,Lawrence Lin,Paul J. Gallins,Amy S. Etheridge,Fred A. Wright,Yi-Hui Zhou,Cliona Molony,Federico Innocenti,Sook Wah Yee,Kathleen M. Giacomini,Nadav Ahituv +16 more
TL;DR: It is shown that activating transcription factor 3 (ATF3), the top metformin upregulated AMPK-dependent gene, could have an important role in gluconeogenesis repression and the findings provide a genome-wide representation of met formin hepatic response.