L
Le A. Trinh
Researcher at University of Southern California
Publications - 33
Citations - 1698
Le A. Trinh is an academic researcher from University of Southern California. The author has contributed to research in topics: Zebrafish & Hyperspectral imaging. The author has an hindex of 15, co-authored 30 publications receiving 1341 citations. Previous affiliations of Le A. Trinh include California Institute of Technology.
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Journal ArticleDOI
Programmable in situ amplification for multiplexed imaging of mRNA expression
Harry M. T. Choi,Joann Y Chang,Le A. Trinh,Jennifer E. Padilla,Scott E. Fraser,Niles A. Pierce +5 more
TL;DR: A multiplexed fluorescent in situ hybridization method based on orthogonal amplification with hybridization chain reactions (HCR), in which RNA probes complementary to mRNA targets trigger chain reactions in which fluorophore-labeled RNA hairpins self-assemble into tethered fluorescent amplification polymers.
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Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Filipa C. Simões,Thomas J. Cahill,Amy Kenyon,Daria Gavriouchkina,Daria Gavriouchkina,Joaquim M. Vieira,Xin Sun,Daniela Pezzolla,Christophe Ravaud,Eva Masmanian,Michael Weinberger,Sarah Mayes,Madeleine E. Lemieux,Damien N. Barnette,Mala Gunadasa-Rohling,Ruth M. Williams,David R. Greaves,Le A. Trinh,Scott E. Fraser,Sarah L. Dallas,Robin P. Choudhury,Tatjana Sauka-Spengler,Paul R. Riley +22 more
TL;DR: An evolutionarily-conserved function of macrophages is identified that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
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Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.
Mark R. Cronan,Rebecca W. Beerman,Allison F. Rosenberg,Joseph W. Saelens,Matthew G. Johnson,Stefan H. Oehlers,Dana M. Sisk,Kristen L. Jurcic Smith,Neil A. Medvitz,Sara E. Miller,Le A. Trinh,Scott E. Fraser,John F. Madden,Joanne Turner,Jason E. Stout,Sunhee Lee,David M. Tobin +16 more
TL;DR: Granuloma macrophages are broadly reprogrammed by epithelial modules, and this reprogramming alters the trajectory of infection and the associated immune response, suggesting that the granuloma can also serve a bacteria-protective role.
Journal ArticleDOI
A versatile gene trap to visualize and interrogate the function of the vertebrate proteome
Le A. Trinh,Tatiana Hochgreb,Matthew J. Graham,David Wu,Frederique Ruf-Zamojski,Chathurani S. Jayasena,Ankur Saxena,Rasheeda Hawk,Aidyl Gonzalez-Serricchio,Alana Dixson,Elly Suk Hen Chow,Constanza Gonzales,Ho-Yin Leung,Ilana Solomon,Marianne Bronner-Fraser,Sean G. Megason,Scott E. Fraser +16 more
TL;DR: The FlipTrap captures the functional proteome, enabling the visualization of full-length fluorescent fusion proteins and interrogation of function by conditional mutagenesis and targeted genetic manipulation.
Journal ArticleDOI
Hyperspectral phasor analysis enables multiplexed 5D in vivo imaging
Francesco Cutrale,Vikas Trivedi,Le A. Trinh,Chi-Li Chiu,John M. Choi,Marcela S Artiga,Scott E. Fraser +6 more
TL;DR: It is shown that HySP enables unmixing of seven signals in time-lapse imaging of living zebrafish embryos and enables denoising and un Mixing multiple spectrally overlapping fluorophores in a low signal-to-noise regime with fast analysis.