M
Michael Weinberger
Researcher at University of Oxford
Publications - 7
Citations - 356
Michael Weinberger is an academic researcher from University of Oxford. The author has contributed to research in topics: Zebrafish & Regeneration (biology). The author has an hindex of 4, co-authored 6 publications receiving 185 citations.
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Journal ArticleDOI
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Filipa C. Simões,Thomas J. Cahill,Amy Kenyon,Daria Gavriouchkina,Daria Gavriouchkina,Joaquim M. Vieira,Xin Sun,Daniela Pezzolla,Christophe Ravaud,Eva Masmanian,Michael Weinberger,Sarah Mayes,Madeleine E. Lemieux,Damien N. Barnette,Mala Gunadasa-Rohling,Ruth M. Williams,David R. Greaves,Le A. Trinh,Scott E. Fraser,Sarah L. Dallas,Robin P. Choudhury,Tatjana Sauka-Spengler,Paul R. Riley +22 more
TL;DR: An evolutionarily-conserved function of macrophages is identified that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
Journal ArticleDOI
PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling
Stefania Monterisi,Miguel J Lobo,Craig Livie,John C Castle,Michael Weinberger,George S. Baillie,Nicoletta C. Surdo,Nshunge Musheshe,Alessandra Stangherlin,Eyal Gottlieb,Rory J Maizels,Mario Bortolozzi,Massimo Micaroni,Manuela Zaccolo +13 more
TL;DR: It is demonstrated that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and PKA-dependent phosphorylation of Drp1, and inhibition of PDE1A, by enhancing the hormone-dependent cAMP response locally, affects mitochondria dynamics and protects from apoptotic cell death.
Journal ArticleDOI
Functional Heterogeneity within the Developing Zebrafish Epicardium
TL;DR: Perturbation of unique gene signatures uncovered specific functions associated with each subpopulation and established epicardial roles in cell adhesion, migration, and chemotaxis as a mechanism for recruitment of leukocytes into the heart.
Posted ContentDOI
Functional heterogeneity within the developing zebrafish epicardium
TL;DR: This work elucidates the mutual spatiotemporal relationships between different epicardial subpopulations and assigns unique function to each during cardiac development, and brings us closer to repairing cellular relationships that are disrupted during cardiovascular disease.
Posted ContentDOI
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
David Ahern,Z Ai,Mark A. Ainsworth,Charlotte L. Allan,A Allcock,A Ansari,Carolina V. Arancibia-Cárcamo,Dominik Aschenbrenner,Moustafa Attar,J K Baillie,E Barnes,Rachael Bashford-Rogers,A. Bashyal,Sally Beer,Georgina Berridge,A Beveridge,S Bibi,Tihana Bicanic,L Blackwell,Paul Bowness,Andrew Brent,Anthony Brown,John Broxholme,David Buck,Katie L. Burnham,Helen M. Byrne,S Camara,I Candido Ferreira,Philip D. Charles,W Chen,Chen Y-L.,Amanda Y. Chong,Elizabeth A. Clutterbuck,Mark Coles,Christopher P. Conlon,Richard J. Cornall,Adam P. Cribbs,F Curion,Emma E. Davenport,N Davidson,Simon J. Davis,Calliope A. Dendrou,J Dequaire,L Dib,J Docker,Christina Dold,Tao Dong,Damien J. Downes,A Drakesmith,Susanna Dunachie,David A. Duncan,C Eijsbouts,R Esnouf,A Espinosa,R Etherington,Benjamin P. Fairfax,Rory Fairhead,H Fang,S Fassih,S Felle,M Fernandez Mendoza,Ricardo C. Ferreira,Roman Fischer,T H Foord,Aden Forrow,John Frater,Anastasia Fries,V Gallardo Sanchez,L Garner,C Geeves,D Georgiou,Laura Godfrey,Tanya Golubchik,M Gomez Vazquez,Angie Green,H Harper,Heather A. Harrington,Raphael Heilig,Svenja Hester,Jennifer Hill,Charles J. Hinds,C Hird,Ho L-P.,Renee S. Hoekzema,B Hollis,Jim R. Hughes,P Hutton,M. Jackson,Ashwin Kumar Jainarayanan,A James-Bott,Kathrin Jansen,Katie Jeffery,E Y Jones,Luke Jostins,G Kerr,David Y. Kim,Paul Klenerman,Julian C. Knight,V Kumar,P. Kumar Sharma,P Kurupati,Andrew J Kwok,Andy C. H. Lee,A Linder,T Lockett,Lorne Lonie,Maria Lopopolo,Martyna Lukoseviciute,J Luo,S Marinou,Brian D. Marsden,Jose Vicente Martinez,Paul M. Matthews,M Mazurczyk,Simon J. McGowan,Stuart McKechnie,Adam J. Mead,Alexander J. Mentzer,Y Mi,Claudia Monaco,R Montadon,Giorgio Napolitani,Isar Nassiri,Alex Novak,D O'Brien,Daniel H. O'Connor,Denise O'Donnell,Graham S. Ogg,L E Overend,I Park,Ian D. Pavord,Y Peng,F Penkava,M Pereira Pinho,E Perez,Andrew J. Pollard,Fiona Powrie,B Psaila,T P Quan,Emmanouela Repapi,S Revale,L Silva-Reyes,Richard J-B.,Charlotte Rich-Griffin,Thomas G Ritter,Christine S. Rollier,Matthew J. Rowland,Fabian Ruehle,Mariolina Salio,Stephen N. Sansom,A Santos Delgado,Tatjana Sauka-Spengler,Ron Schwessinger,G Scozzafava,Gavin R. Screaton,Anna Seigal,Malcom G Semple,Martin J. Sergeant,C Simoglou Karali,David Sims,Donal T. Skelly,Hubert Sławiński,A Sobrinodiaz,N Sousos,Lizzie Stafford,Lisa Stockdale,M Strickland,O Sumray,B Sun,Chelsea A Taylor,Stephen S. Taylor,Aimee R. Taylor,Supat Thongjuea,H Thraves,John A. Todd,Adriana Tomic,O Tong,Amy Trebes,Dominik Trzupek,F A Tucci,Lance Turtle,Irina A. Udalova,Holm H. Uhlig,E van Grinsven,Iolanda Vendrell,M Verheul,A Voda,G Wang,Linwei Wang,D Wang,Peter J. Watkinson,Robert A. Watson,Michael Weinberger,Justin P. Whalley,Lorna Witty,K Wray,L Xue,H Y Yeung,Z Yin,R K Young,Jonathan Youngs,P Zhang,Zurke Y-X. +202 more
TL;DR: In this article, a comprehensive multi-omic blood atlas was presented in patients with varying COVID-19 severity and compare with influenza, sepsis and healthy volunteers, identifying immune signatures and correlates of host response.