Cholsoon Jang

TL;DR: It is found that lactate can be a primary source of carbon for the TCA cycle and thus of energy, and during the fasted state, the contribution of glucose to tissue TCA metabolism is primarily indirect (via circulating lactate) in all tissues except the brain.

TL;DR: The basics of metabolite measurement by MS are described, including sample preparation, metabolomic analysis, and data interpretation, and the ways in which metabolomics and isotope tracing can illuminate biology are highlighted.

TL;DR: The data indicate that PPCM is mainly a vascular disease, caused by excess anti-angiogenic signalling in the peripartum period, and explain how late pregnancy poses a threat to cardiac homeostasis, and why pre-eclampsia and multiple gestation are important risk factors for the development of P PCM.

TL;DR: It is proposed that the small intestine shields the liver from otherwise toxic fructose exposure, finding that dietary fructose is cleared by theSmall intestine, both by prior exposure to fructose and by feeding.

TL;DR: PPARGC1a is leveraged, a transcriptional coactivator that regulates broad programs of fatty acid consumption, to identify 3-hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, as a new paracrine regulator of trans-endothelial fatty acid transport, providing a mechanistic explanation for how increased BCAA catabolic flux can cause diabetes.